Thesis Astrid Thielen

On 11 January 2019 Astrid Thielen defended her PhD thesis 'Regulation of complement activation on red blood cells' at the University of Amsterdam.

Promotores: Prof S.S. Zeerleder MD PhD and prof S.M. van Ham PhD
Co-promotor: D. Wouters PhD
Venue: Agnietenkapel, University of Amsterdam

Chapters

Chapter 1
Introduction and scope of this thesis

Chapter 2
Consequences of dysregulated complement regulators on red blood cells Abstract

Chapter 3
Complement regulator CD46 expression is lost gradually during erythropoiesis and enucleation

Chapter 4
Complement deposition and IgG binding on stored red blood cells are independent of storage time

Chapter 5
Blocking the binding region domains 6-8 of factor H inhibits its complement regulation function on human red blood cells

Chapter 6
CRISPR/Cas9 generated human CD46, CD55 and CD59 knockout cell lines as a tool for complement research Abstract

Chapter 7
The amplification loop is not required for efficient classical complement pathway activation

Chapter 8
Summarizing discussion

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Download PhD thesis (university repository)

Thesis Astrid Thielen