Thesis Margit Boshuizen
On 18 December 2019 (14:00) Margit Boshuizen defended her PhD thesis 'Modulating iron metabolism in anemia of inflammation in the critically ill'.
Promotores: Prof Nicole Juffermans MD PhD and Prof Marcus Schultz MD PhD
Copromotor: Robin van Bruggen PhD
Venue: Agnietenkapel, University of Amsterdam
Abstract
This thesis extends our knowledge on iron metabolism in anemia of inflammation (AI) in the critically ill. It shows that AI may be a separate entity, that occurs already prior to the development of anemia and that AI may be diagnosed with commonly available iron parameter tests. This provides us a window of opportunity to treat AI before the anemia arises. We show that red blood cell (RBC) transfusion is not favourable to iron metabolism. Furthermore, this thesis contributes to our insight of the applications of transferrin. We show that an alternative treatment with the use of transferrin is not effective in reducing the occurrence of anemia in AI but may serve as a factor to limit non-transferrin bound iron (NTBI)-induced inflammation. Also, we develop a relevant AI model in which other treatments can be evaluated.
Chapters
Chapter 1
General introduction
Chapter 2
Iron metabolism in critically ill patients developing anemia of inflammation; a case control study Abstract
Chapter 3
Diagnostic characteristics of parameters of iron metabolism for the development of anemia of inflammation in ICU patients
Chapter 4
The effect of red blood cell transfusion on iron metabolism in critically ill patients Abstract
Chapter 5
Therapeutic use of transferrin to modulate anemia and conditions of iron toxicity Abstract
Chapter 6
Development of a model for anemia of inflammation that is relevant to critical care Abstract
Chapter 7
Iron therapy to treat anemia of inflammation is not improved by transferrin supplementation
Chapter 8
Effects of apotransferrin vs placebo as an adjunct therapy to red blood cell transfusion on levels of free iron, bacterial outgrowth and organ injury in a rat pneumonia model
Chapter 9
General discussion
Download
Download PhD thesis (university repository)