Thesis Lydian de Ligt
On 4 June 2026 (4:00 PM) Sanquin researcher Lydian de Ligt expects to defend her PhD thesis 'Breaking the cycle. Targeting the interplay between red blood cells and inflammation in sickle cell disease' at the University of Amsterdam
Promotores
Prof K Fijnvandraat MD PhD
Prof BJ Biemond MD PhD
Co-promotores
E Nur MD PhD
R van Bruggen PhD
Venue
University of Amsterdam, Agnietenkapel
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abstract (to follow)
Chapters
Chapter 1
General introduction and outline of this thesis
I. Optimizing red blood cell transfusion in sickle cell disease
Chapter 2
Withholding transfusion therapy in children with sickle cell disease with abnormal transcranial doppler and normal magnetic resonance angiography: a retrospective analysis abstract
Chapter 3
Red blood cell survival in sickle cell disease: explaining interindividual heterogeneity
Chapter 4
Effect of red blood cell transfusion on inflammatory and angiogenic pathways in patients with sickle cell disease abstract
II. Unraveling disease pathophysiology to identify potential therapeutic targets
Chapter 5
Neutrophils in sickle cell disease: exploring their potential role as a therapeutic target abstract
Chapter 6
Dynamics of neutrophil phenotype and functionality in sickle cell disease abstract
Chapter 7
Plasma inflammatory and angiogenic protein profiling of patients with sickle cell disease abstract
Chapter 8
Effect of hematopoietic cell transplantation on inflammatory and angiogenic plasma proteins in sickle cell disease abstract
Chapter 9
Alterations in clot characteristics in sickle cell disease are mediated by ICAM-4 and normalized by red blood cell transfusions
Chapter 10
Low-dose iron chelation as anti-oxidative therapy in patients with sickle cell disease; a single-center pilot study abstract
Chapter 11
Artificial intelligence-based imaging flow cytometry for assessing sickle cell disease severity and drug efficacy
Chapter 12
General discussion and future perspectives
Download thesis
Download thesis from university repository (when available)