Thesis Caroline Hochheuser
On 18 May 2026 (4:15 PM) Sanquin researcher Caroline Hochheuser expects to defend her PhD thesis 'The bone marrow as a metastatic niche in neuroblastoma. Impact of metastasis on tumor-, mesenchymal stromal cell- and hematopoietic stem cell niches' at the Utrecht University
Promotores
Prof JJ Molenaar MD PhD
Prof GAM Tytgat MD PhD
Co-promotores
I Timmerman PhD
C Voermans PhD
Venue
Utrecht University, Academy Building
Join online
PLEASE NOTE: The candidate gives a layman's talk, therefore the livestream will start fifteen minutes earlier.
Abstract (to follow)
Chapters
Chapter 1
General introduction
Chapter 2
Single-cell analysis of paired neuroblastoma tumor and bone marrow metastases reveals tumor heterogeneity and metastatic subpopulations with therapy-resistant characteristics
Chapter 3
Mesenchymal Stromal Cells in Neuroblastoma: Exploring Crosstalk and Therapeutic Implications abstract
Chapter 4
The Metastatic Bone Marrow Niche in Neuroblastoma: Altered Phenotype and Function of Mesenchymal Stromal Cells abstract
Chapter 5
Exploring MSC-neuroblastoma interactions: Proliferation and chemosensitivity of adrenergic and mesenchymal tumor cells and the role of CD146/MGAM for bi-directional crosstalk
Chapter 6
PEGylated Granulocyte Colony-Stimulating Factor and Plerixafor Enhance Autologous Stem and Progenitor Cell Mobilization and Transplantation in Pediatrie Patients abstract
Chapter 7
The Potential of Mesenchymal Stromal Cells in Neuroblastoma Therapy for Delivery of Anti-Cancer Agents and Hematopoietic Recovery abstract
Chapter 8
Discussion
Download thesis
Download PhD thesis from university repository (when available)