Thesis Tim Postmus
On 19 February 2026, Sanquin researcher Tim Postmus defended his PhD thesis 'Towards novel therapies of ITTP: Defining and shielding of antibody epitopes on ADAMTS13 '
at the University of Amsterdam
Promotor: Prof JJ Voorberg PhD
Copromotor: GAF Nicolaes PhD
Abstract (to follow)
Chapters
Chapter 1
General Introduction
Chapter 2
Trpl250, Lysl252 and Argl367 of ADAMTS13 comprise a hot-spot for anti-CUB domain antibodies in patients with iTTP abstract
Chapter 3
Impact of N-glycan mediated shielding of ADAMTS13 on the binding of pathogenic antibodies in immune thrombotic thrombocytopenic purpura abstract
Chapter 4
N-glycan shielded CUB domains of ADAMTS13 prevent binding of C-terminal antibodies in patients with immune-mediated TTP abstract
Chapter 5
Site-specific citrullination of ADAMTS13 reveals impact of arginine deimination on activity
Chapter 6
Unbiased plasma proteomics reveals hemolysis during ADAMTS13 relapse in patients with immune TTP
Chapter 7
General discussion
Download thesis
Download thesis from university repository (when available)