Thesis Lieke van Zogchel

Chapter 1
Introduction and outline of this thesis

Part I Minimal residual disease in neuroblastoma
Chapter 2
Sensitive liquid biopsy monitoring correlates with outcome in the prospective international GPOH-DCOG high-risk neuroblastoma RT-qPCR validation study abstract

Chapter 3
Detection of Minimal Residual Disease in Peripheral Blood Samples of High-Risk Neuroblastoma Patients Correlates with Outcome: Final Results of International GPOH-DCOG Prospective Validation Study

Chapter 4
Mesenchymal neuroblastoma cells are undetected by current mRNA marker panels: the development of a specific neuroblastoma mesenchymal MRD panel abstract

Chapter 5
Specific and sensitive detection of neuroblastoma mRNA markers by multiplex RT-qPCR

Chapter 6
The Metastatic Bone Marrow Niche in Neuroblastoma: Altered Phenotype and Function of Mesenchymal Stromal Cells abstract

Part II Cell free DNA in pediatric solid tumors
Chapter 7
Hypermethylated RASSF1A as circulating tumor DNA marker for disease monitoring in neuroblastoma abstract

Chapter 8
Novel circulating hypermethylated RASSF1A ddPCR for liquid biopsies in patients with pediatric solid tumors abstract

Chapter 9
Cell-free DNA as a diagnostic and prognostic biomarker in pediatric rhabdomyosarcoma abstract

Chapter 10
Combining hypermethylated RASSF1A detection using droplet digital PCR with miR-371a-3p testing: an improved and highly sensitive panel of liquid biopsy biomarkers for testicular germ cell tumor patients abstract

Chapter 11
Targeted Locus Amplification to develop robust patient-specific assays for liquid biopsies in pediatric solid tumors abstract

Chapter 12
General discussion