References

Our references for Erythroblast outgrowth, Induced pluripotent stem cell (iPSC) differentiation and induced pluripotent stem cell lines derived at Sanquin.

Sanquin EBL outgrowth

1. Akker et.al. The majority of the in vitro erythroid expansion potential resides in CD34(−) cells, outweighing the contribution of CD34(+) cells and significantly increasing the erythroblast yield from peripheral blood samples. Haematologica, 2010 Sep. 95 (9), 1594–1598. [Pubmed]

2. Heideveld et.al. CD14+ cells from peripheral blood positively regulate hematopoietic stem and progenitor cell survival resulting in increased erythroid yield. Haematologica, 2015 Nov. 100 (11), 1396–1406. [Pubmed]

3. Heshusius et.al. Large-scale in vitro production of red blood cells from human peripheral blood mononuclear cells. Blood Adv. 2019 Nov 12;3(21):3337-3350. [Pubmed]

Sanquin iPSC differentiation and reviews

4. Hansen et.al. Human-induced pluripotent stem cell-derived blood products: state of the art and future directions. FEBS Lett. 2019 Sep 14. [Pubmed]

5. Hansen, Varga, Aarts et.al. Efficient production of erythroid, megakaryocytic and myeloid cells, using single cell-derived iPSC colony differentiation. Stem Cell Res. 2018 May;29:232-244. [Pubmed]

6. Varga, Hansen et.al. Erythropoiesis and Megakaryopoiesis in a Dish. IntechOpen, November 5th 2018, Book chapter [Reference Link]

Sanquin iPSC lines

7. Hansen et.al. Generation and characterization of human iPSC line MML-6838-Cl2 from mobilized peripheral blood derived megakaryoblasts. Stem Cell Res. 2017 Jan;18:26-28. [Pubmed]

8. Hansen, Varga et.al. Generation and characterization of human iPSC lines SANi001-A and SANi002-A from mobilized peripheral blood derived megakaryoblasts. Stem Cell Res. 2017 Dec;25:42-45. [Pubmed]

9. Hansen, Varga et.al. Generation and characterization of a human iPSC line SANi005-A containing the gray platelet associated heterozygous mutation p.Q287* in GFI1B. Stem Cell Res. 2017 Dec;25:34-37. [Pubmed]

10. Varga, Hansen et.al. Generation of human erythroblast-derived iPSC line using episomal reprogramming system. Stem Cell Res. 2017 Dec;25:30-33. [Pubmed]

Selected publication using iPSC lines derived at Sanquin

11. Mandoli et.al. The Hematopoietic Transcription Factors RUNX1 and ERG Prevent AML1-ETO Oncogene Overexpression and Onset of the Apoptosis Program in t(8;21) AMLs. Cell Rep. 2016 Nov 15;17(8):2087-2100. [Pubmed]

12. Oorschot et.al. Molecular mechanisms of bleeding disorder associated GFI1BQ287* mutation and its affected pathways in megakaryocytes and platelets. Haematologica. 2019 Jul;104(7):1460-1472. [Pubmed]

13. Theil et.al. Trichothiodystrophy causative TFIIEβ mutation affects transcription in highly differentiated tissue. Hum Mol Genet. 2017 Dec 1;26(23):4689-4698. [Pubmed]

14. Yi et.al. CBFβ-MYH11 interferes with megakaryocyte differentiation via modulating a gene program that includes GATA2 and KLF1. Blood Cancer J. 2019 Mar 8;9(3):33. [Pubmed]

Others

15. Takahashi and Yamanaka. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell. 2006 Aug 25;126(4):663-76. [Pubmed]

16. Takahashi et.al. Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell. 2007 Nov 30;131(5):861-72. [Pubmed]

17. Nishimura et.al. Development of defective and persistent Sendai virus vector: a unique gene delivery/expression system ideal for cell reprogramming. J Biol Chem. 2011 Feb 11;286(6):4760-71. [Pubmed]