Blood-borne Infections

Prof Mariet (M.C.W.) Feltkamp, MD PhD

Sanquin is committed to provide pathogen-free products for transfusion and plasma-derived medical products. We study known, less known and (re)emerging blood-borne infections and related pathogens, to learn about potential consequences and advice about donor screening, donor deferral and donor eligibility.

Groupleader

Prof Mariet (M.C.W.) Feltkamp, MD PhD

m.feltkamp@sanquin.nl

Mariet Feltkamp

Research lines

Classical blood-borne pathogens: HIV, Hepatitis B, C and D Virus, Human T-cell Leukemia Virus and Treponema pallidum.
Other blood-borne viruses: Hepatitis A and E virus, Parvovirus B19, Torque teno virus.

Collaboration partners

Center for Infectious Diseases, LUMC Leiden;
Center for Proteomics and Metabolomics, LUMC Leiden;
Dept of Pediatrics, AUMC Amsterdam;
Medical University Vienna,
ISBT working party on TTID,
BEST collaborative

Key publications

1) T. van de Laar, L. Patmore, M. Molier, M. Sonneveld, J. Voermans, E. Slot, M. Feltkamp, A. van der Eijk H. Zaaijer. Low rate of hepatitis Delta virus co-infection in first-time blood donors diagnosed with chronic hepatitis B virus infection in the Netherlands. Transfusion 2025; 65: 841-847.

F. Quee, E. Slot, I. van Leeuwen, R. Brands, E. Franssen, B. Hogema, H. Zaaijer, T. van de Laar. Blood safety markers in Dutch donors after relaxation of deferral for men who have sex with men: Re-emergence of syphilis and HIV pre-exposure prophylaxis use. Transfusion 2024; 64: 1732-1742.

Molenaar-de Backer MW, Hogema BM, Koppelman MH, van de Laar TJ, Slot E, Zaaijer HL. Lower Incidence of Parvovirus-B19 Infections in Dutch Blood Donors during SARS-CoV-2 Pandemic. Microbiol Spectr 2021; 9(2):e0025321.

T. van de Laar, B. Hogema, M. Molenaar-de Backer, T. Marijt-van der Kreek, H. Zaaijer. Blood donor screening in the Netherlands: universal anti-HBc screening in combination with HBV nucleic acid amplification testing may allow discontinuation of hepatitis B virus antigen testing. Transfusion 2021; 61: 2116-2124.

Vinkenoog M, Steenhuis M, Brinke AT, van Hasselt JGC, Janssen MP, van Leeuwen M, Swaneveld FH, Vrielink H, van de Watering L, Quee F, van den Hurk K, Rispens T, Hogema B, van der Schoot CE. Associations between symptoms, donor characteristics and IgG antibody response in COVID-19 Convalescent Plasma Donors. Front Immunol 2022; 13:821721.

S. Kamminga, E. van der Meijden, C. de Brouwer, M. Feltkamp, H. Zaaijer. Prevalence of DNA of fourteen human polyomaviruses determined in blood donors. Transfusion 2019; 59:3689-3697

W van Bilsen, H Zaaijer, A Matser, K van den Hurk, E Slot, F Schim van der Loeff, M Prins, T van de Laar. Infection pressure in men who have sex with men and their suitability to donate blood. Clinical Infectious Diseases 2019; 68: 1001-1008.

S. Kamminga, E. van der Meijden, H. Wunderink, A. Touzé, H. Zaaijer, M. Feltkamp. Development and evaluation of a bead-based multiplex immunoassay to measure IgG seroreactivity against human polyomaviruses. J Clin Microbiol 2018; 56:e01566-17.

S. Kamminga, E. van der Meijden, M. Feltkamp, H. Zaaijer. Seroprevalence of fourteen human polyomaviruses determined in blood donors. PLoS One 2018;13:e0206273

T van de Laar, V Van Gaever, P van Swieten, A Muylaert, V Compernolle, H Zaaijer. Phylogenetic analysis reveals three distinct epidemiological profiles in Dutch and Flemish blood donors with hepatitis B infection. Virology 2018; 515: 243-249.

T van de Laar, ,D. Bezemer, K van Laethem, G Vandewalle, A de Smet, E van Wijngaerden, E Claas, A van Sighem, A-M Vandamme, V Compernolle, H Zaaijer. Phylogenetic evidence for underreporting of male-to-male sex among human immunodeficiency virus-infected donors in the Netherlands and Flanders. Transfusion 2017; 57: 1235-1247.