Landsteiner lecture by Margaret A. Goodell | Clonal Hematopoiesis and Early Embryonic Mosaicism

Medical priority Anemia

Wednesday 5 November Margaret A. Goodell PhD, Baylor College of Medicine, Houston, USA will give a Landsteiner Lecture  at  Sanquin Amsterdam.

Hosts: Gerald de Haan and Arthur Svendsen

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We are interested in the basic biology of hematopoietic stem cells. It has been known for decades that hematopoietic stem cells reside in the bone marrow in a quiescent state and replenish the supply of differentiated cells of the peripheral blood throughout the lifetime of an animal. No other adult cell type retains the capacity for such immense proliferation and differentiation. However, little is known about the cells or factors that regulate their primitive state or control their activation. We study the behavior of these stem cells in vivo and in vitro using mouse stem cells as a model, as well as pursue the mechanisms which control their behavior on a molecular level using genome-wide profiling strategies and mouse mutants.