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Tom (TP) Plug

Plasma Proteins

Medical Biology

Research interests

Red blood cells, Factor XIII, Fibrin, Thrombin-activatable Fibrinolysis Inhibitor (TAFI), Fibrinolysis, Enzyme kinetics.

2015-present Junior Post-doc at the Dept of Plasma Proteins, Sanquin Research
2012-2015 PhD student at the AMC Amsterdam, Dept of Experimental Vascular Medicine
2004-2015 Research Technician at the AMC Amsterdam, Dept of Experimental Vascular Medicine
2003-2004 Internship at the VUmc Amsterdam, Dept of Oncological Gyneacology
2002 Internship at the LUMC Leiden, Dept of Human Genetics
Sanquin publications
Other publications

Plug T, Meijers JC. Structure-function relationships in Thrombin-activatable Fibrinolysis Inhibitor. J Thromb Haemost 2016 Jan 20.

Plug T, Marquart JA, Marx PF, Meijers JC. Selective modulation of thrombin-activatable Fibrinolysis Inhibitor (TAFI) activation by thrombin or the thrombin-thrombomodulin complex using TAFI-derived peptides. J Thromb HaemosT 2015; 13(11):2093-101.

Naudin C, Hurley SM, Malmstrom E, Plug T, Shannon O, Meijers JCM, Morgelin M, Bjorck L, Herwald H. Active but inoperable thrombin is accumulated in a plasma protein layer surrounding Streptococcus pyogenes. Thromb Haemost 2015; 114(4):717-26.

Plug T, Meijers JCM. New clues regarding the mysterious mechanism of activated thrombin-activatable fibrinolysis inhibitor self-destruction. J Thromb Haemost 2015; 13(6):1081-3.

Plug T, Kramer G, Meijers JCM. A role for arginine-12 in thrombin/thrombomodulin-mediated activation of thrombin-activatable fibrinolysis inhibitor. J Thromb Haemost 2014; 12(10):1717-25.

Hashemi Shabestari M, Plug T, Motazacker MM, Meeuwenoord NJ, Filippov DV, Meijers JCM, Huber M. The aggregation potential of the amyloid beta peptide and their influence on aggregation of Abeta40. Applied Magnetic Resonance 2013; 10.1007/s00723-013-0469-3

Valls Seron M, Plug T, Marquart JA, Marx PF, Herwald H, de Groot PhG, Meijers JCM. Binding characteristics of thrombin-activatable fibrinolysis inhibitor to streptococcal surface collagen-like proteins A and B. Thromb Haemost 2011; 106(4):609-16.

Marx PF, Plug T, Havik SR, Mörgelin M, Meijers JCM. The activation peptide of thrombin-activatable fibrinolysis inhibitor: a role in activity and stability of the enzyme? J Thromb Haemost 2009; 7(3):445-52.

Marx PF, Brondijk THC, Plug T, Romijn RA, Hemrika W, Meijers JCM, Huizinga EG. Crystal structures of TAFI elucidate the inactivation mechanism of activated TAFI: a novel mechanism for enzyme autoregulation. Blood 2008:112(7):2803-9.

Last edited on: 21 April 2016
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