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Ruben (R) Bierings PhD

Plasma Proteins

Molecular and Cell biology


‘Sorting out the Weibel-Palade body’
17 October 2007
Promotores: Prof K Mertens
Co-promotores: JA Mourik PhD and J Voorberg PhD

Research interests

Endothelial secretory pathway: biogenesis, maturation and exocytosis of Weibel-Palade bodies.

  • Live cell imaging
  • Proteomics
  • Purification of recombinant proteins
2013-present European Hematology Senior Research Fellow at the Dept of Plasma Proteins, Sanquin Research, Amsterdam, The Netherlands
2011-present Senior Postdoctoral Fellow at the Dept of Plasma Proteins, Sanquin Research, Amsterdam, The Netherlands
2007-2011 Career Development Fellow at Division of Molecular Neuroendocrinology, MRC National Institute for Medical Research, London, United Kingdom
2002-2007 PhD student at Dept of Plasma Proteins, Sanquin Research, Amsterdam, The Netherlands
2002 MSc Molecular Sciences, Wageningen University, Wageningen, The Netherlands
2001-2002 Visiting scientist at Department of Molecular, Cellular and Developmental Biology, University of California Santa Barbara, United States of America
Sanquin publications
Other publications

Conte IL, Hellen N, Bierings R, Mashanov GI, Manneville JB, Kiskin NI, Hannah MJ, Molloy JE, Carter T. Interaction between MyRIP and the actin cytoskeleton regulates Weibel-Palade body trafficking and exocytosis.
J Cell Sci 2016; 129(3):592-603.

Conte IL, Cookson E, Hellen N, Bierings R, Mashanov G, Carter T. Is there more than one way to unpack a Weibel-Palade body? Blood 2015; 126(18):2165-7.

Bierings R, Hellen N, Kiskin N, Knipe L, Fonseca AV, Patel B, Meli A, Rose M, Hannah MJ, Carter T. The interplay between the Rab27A effectors Slp4-a and MyRIP controls hormone-evoked Weibel-Palade body exocytosis. Blood 2012; 120(13):2757-67.

Knipe L, Meli A, Hewlett L, Bierings R, Dempster J, Skehel P, Hannah MJ, Carter T. A revised model for the secretion of tPA and cytokines from cultured endothelial cells. Blood 2010; 116(12):2183-91.

Derry WB, Bierings R, van Iersel M, Satkunendran T, Reinke V, Rothman JH. Regulation of developmental rate and germ cell proliferation in Caenorhabditis elegans by the p53 gene network. Cell Death Differ 2007; 14(4):662-70.

Last edited on: 2 May 2016
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