Lilian (L) Schimmel
- Molecular Cell Biology
- Biomedical Sciences
- Research interests
More than 80% of all cardiovascular deaths in developed countries occurs in the population aged 65 or over, making aging a major risk factor for cardiovascular disease. It is known that the extracellular matrix (ECM) of the intima in the blood vessels becomes more rigid with age and affects the vascular cell’s phenotype, resulting in inflammation, hypertension and ultimately atherosclerosis and aneurisms.
We hypothesize that increased intima ECM stiffness promotes the sensitivity of the vascular wall for inflammatory responses, resulting in increased leukocyte extravasation, earlier on-set of atherosclerosis and increased risk on abdominal aortic aneurysm (AAA). Therefore, our focus is to understand to what extent ECM rigidity regulates inflammatory signals of vascular cells and consequent processes such as leukocyte transendothelial migration (TEM).
- Cell culturing
- Western blotting
- Confocal microscopy and live cell imaging
- In vitro flow assays
- Pulldown and immunoprecipitation assays for analysis of protein-protein interactions
2014-present PhD student at the Dept of Molecular Cell Biology, Sanquin Research, Amsterdam, The Netherlands 2013 MSc degree in Biomedical Sciences master programme Biology of Disease, Universiteit Utrecht 2012-2013 Internship at the Dept of Cell Biology, NKI-AVL, Amsterdam 2011-2012 Internship at the Dept of Cell Biology, UMC Utrecht 2011 BSc degree in Biomedical Sciences, Universiteit Utrecht
- Sanquin publications