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Josse ( J) van Galen PhD

Plasma Proteins

Molecular Biology and Cell Biology

Molecular aspects of GAPR-1 interactions with biological and model membranes

Research interests

Mechanism of factor VIII clearance

2015-presentPost-doctoral fellow at the Dept of Plasma Proteins, Sanquin Research
2008-2015Postdoctoral Researcher at the Division of Cell and Developmental Biology, Centre for Genomic Regulation, Barcelona, Spain
2003-2008PhD student at the Dept of Biochemistry and Cell Biology, Faculty of Veterinary Medicine, Utrecht University, The Netherlands
1997-2003Bachelor / MSc Biomedical Sciences, Utrecht University, The Netherlands


Other professional activities

Villeneuve J, Duran J, Scarpa M, Bassaganyas L, van Galen J, Malhotra V. Golgi enzymes do not cycle through the endoplasmic reticulum during protein secretion or mitosis. Mol Biol Cell 2016 Nov 2[Epub ahead of print].

Sanquin publications
Other publications

van Galen J*, Campelo F*, Martínez-Alonso E, Scarpa M, Martínez-Menárguez J Á, MalhotraV. Sphingomyelin homeostasis is required to form functional enzymatic domains at the trans-Golgi network. J Cell Biol 2014; 260(5):609-18.

Wakana Y, Villeneuve J*, van Galen J*, Cruz-Garcia D*, Tagaya, Malhotra V. Kinesin-5/Eg5 is important for transport of CARTS from the trans-Golgi network to the cell surface. J Cell Biol 2013; 202(2):241-50.

Duran JM*, Campelo F*, van Galen J*, Sachsenheimer T, Sot J, Egorov MV, Rentero C, Enrich C, Polishchuk RS, Goni FM, Brugger B, Wieland F, Malhotra V. Sphingomyelin organization is required for vesicle biogenesis at the Golgi complex. EMBO J 2012; 31(24):4535-46.

Wakana Y, van Galen J, Meissner F, Scarpa M, Polishchuk RS, Mann M, Malhotra V. A new class of carriers that transport selective cargo from the trans Golgi network to the cell surface. EMBO J 2012; 31(20):3976-90.

van Galen J*, Olrichs NK*, Schouten A, Serrano RL, Nolte-'t Hoen EN, Eerland R, Kaloyanova D, Gros P, Helms JB. Interaction of GAPR-1 with lipid bilayers is regulated by alternative homodimerization. Biochim Biophys Acta 2012; 1818(9):2175-83.

von Blume J, Alleaume AM, Cantero-Recasens G, Curwin A, Carreras-Sureda A, Zimmermann T, van Galen J, Wakana Y, Valverde MA, Malhotra V. ADF/cofilin regulates secretory cargo sorting at the TGN via the Ca2+ ATPase SPCA1. Dev Cell 2011; 20(5):652-62.

Van Galen J, Van Balkom BW, Serrano RL, Kaloyanova D, Eerland R, Stuven E, Helms JB. Binding of GAPR-1 to negatively charged phospholipid membranes: unusual binding characteristics to phosphatidylinositol. Mol Membr Biol 2010; 27(2-3):81-91.

van der Meer-Janssen YP*, van Galen J*, Batenburg JJ, Helms JB. Lipids in host-pathogen interactions: pathogens exploit the complexity of the host cell lipidome. Prog Lipid Res 2010; 49(1):1-26.

* Equal contribution

Last edited on: 21 November 2016
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