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Jaap (JD) van Buul PhD

Molecular Cell Biology

Cell Biology and Biochemistry

'Signalling in leukocyte transendothelial migration: a roadmap for homing of progenitor cells'
May 2004 - University of Amsterdam
Research interests

Signalling pathways that facilitate leukocyte passage across endothelial monolayers. The current focus is directed to small GTPases, such as Rac1, RhoA and RhoG that play an important role in the integrity of the endothelial monolayer.

  • Molecular and Cell Biology techniques such as cloning, culturing cells, transfections
    Confocal laser scanning microscopy in 4D (3D in time)
  • Classical biochemistry assays such as pull downs and immunoprecipitations and
  • Western blotting

Jaap studied Medical Biology at the University of Amsterdam, followed by a PhD training in the lab of Dr. Peter Hordijk. He finished his thesis in May 2004 and continued his research life in the US. He did his post-doctoral training in the lab of Professor Keith Burridge at the University of North Carolina in Chapel Hill from July 2004 until July 2006. Currently, he works as an E. Dekker research fellow (Hartstichting) in the department of Molecular Cell Biology at Sanquin Research in Amsterdam, studying signalling pathways that are involved in transendothelial migration of leukocytes.

Sanquin publications
Other publications

Wittchen ES, van Buul JD, Burridge K, Worthylake RA. Trading spaces: Rap, Rac, and Rho as architects of transendothelial migration. Curr Opin Hematol 2005; 12(1):14-21. Review.

van den Berg AA, van Buul JD, Ostrow JD, Groen AK. Measurement of cholesterol gallstone growth in vitro. J Lipid Res 2000; 41(2):189-94.

van den Berg AA, van Buul JD, Tytgat GN, Groen AK, Ostrow JD. Mucins and calcium phosphate precipitates additively stimulate cholesterol crystallization. J Lipid Res 1998; 39(9):1744-51

Last edited on: 1 July 2016
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