Diana (D) Wouters PhD
Assessment of complement activation in human disease
Promotors: Prof. Dr. L.A. Aarden and Prof. dr. C.E. Hack
June 2008 - University of Amsterdam
- Research interests
The balance between activation and regulation of the complement system in human disease.
Complement is part of the innate immune response and upon activation of the complement system very powerful inflammatory reactions are induced. Therefore it is important to tightly regulate complement activation under normal conditions. To control the process of complement activation, complement regulatory proteins are present in plasma and on host cell membranes.
Uncontrolled complement activation by either excessive activation or lack of regulation may lead to disease. We are studying the delicate balance between complement activation and regulation under normal healthy conditions and in diseases such as atypical Hemolytic Uremic syndrome (aHUS) and SLE (systemic lupus erythematosus). Currently we are focusing on the following subjects:
- Complement activity in oncology patients
- Function of the inhibitory protein factor H
- Control mechanisms of the lectin pathway
- Affinity chromatography
- Gel electrophoresis
- Western blot
2007-present Post-doc at Dept of Immunopathology, subgroup Autoimmune diseases, Sanquin Research, Amsterdam 2001-2007 PhD student at Dept of Immunopathology, Sanquin research, Amsterdam 1996-2000 Medical Biology at the Free University of Amsterdam
- Sanquin publications