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Aniska (A) Chhatta

Experimental Immunohematology

Bsc Immunology (HLO, Hanzehogeschool Groningen)
Msc Medical Biology (VU University Amsterdam)

Research interests

Elucidation of the working mechanism of Rh immunoprophylaxis.
Prevention of Rh immunization by the administration of anti-D immunoglobulin is one of the most widespread, successful applications of immuno’therapy’. Before the introduction of the RhD prophylaxis haemolytic disease of the newborn caused by anti-RhD antibodies was one of the major causes of perinatal deaths (10%). For more than 30 years anti-D immunoglobulin has been given to D-negative women’s after delivery of a D+ child. Without Rh prophylaxis the prevalence of Rh immunization developing after delivery of an RhD positive child is about 12%. Although postnatal Rh immunoprophylaxis reduces the immunization rate by 90%, the suppressive mechanism is still poorly understood. This lack of insight in the working mechanism hampers the introduction of monoclonal IgG for Rh immunoprophylaxis. Furthermore, it is difficult to develop strategies to increase its effectiveness. In the Netherlands still at least 100 pregnant women a year show RhD immunization.

  • (Stem) Cell Culture
  • Flow cytometry
  • Cloning
2013-presentResearch technician at the Dept of Experimental Immunohematology at Sanquin Research
2012-1013Serology technician at the Dept of Leucocyte/thrombocyte serology at Sanquin Diagnostic Services
2009-2012Genetic Counselor in training at the Dept of Clinical Genetics at AMC Amsterdam
2006-2009Research technician at the Dept of Experimental Immunohematology at Sanquin Research
2003-2006Research technician at the Tytgat Institute for Liver and Intestinal Research Amsterdam
Sanquin publications
Other publications

Deurholt T, van Til NP, Chhatta AA, ten Bloemendaal L, Schwartlander R, Payne C, Plevris JN, Sauer IM, Chamuleau RA, Elferink RP, Seppen J, Hoekstra R. Novel immortalized human fetal liver cell line, cBAL111, has the potential to differentiate into functional hepatocytes. BMC Biotechnol 2009; 9:89.

Poyck PP, Hoekstra R, Chhatta AA, Bloemendaal LT, van Wijk AC, Galavotti D, van Gulik TM, Chamuleau RA. Time-related analysis of metabolic liver functions, cellular morphology, and gene expression of hepatocytes cultured in the bioartificial liver of the Academic Medical Center in Amsterdam (AMC-BAL). Tissue Eng 2007; 13(6):1235-46.

Westerman BA, Breuer RH, Poutsma A, Chhatta A, Noorduyn LA, Koolen MG, Postmus PE, Blankenstein MA, Oudejans CB. Basic helix-loop-helix transcription factor profiling of lung tumors shows aberrant expression of the proneural gene atonal homolog 1 (ATOH1, HATH1, MATH1) in neuroendocrine tumors. Int J Biol Markers 2007; 22(2):114-23.

Deurholt T, ten Bloemendaal L, Chhatta AA, van Wijk AC, Weijer K, Seppen J, Elferink RP, Chamuleau RA, Hoekstra R. In vitro functionality of human fetal liver cells and clonal derivatives under proliferative conditions. Cell Transplant 2006; 15(8-9):811-22.

Huisman MT, Chhatta AA, van Tellingen O, Beijnen JH, Schinkel AH. MRP2 (ABCC2) transports taxanes and confers paclitaxel resistance and both processes are stimulated by probenecid. Int J Cancer 2005; 116(5):824-9.

Hoekstra R, Deurholt T, Poyck PP, ten Bloemendaal L, Chhatta AA. Increased reproducibility of quantitative reverse transcriptase-PCR. Anal Biochem 2005; 340(2):376-9.

Westerman BA, Chhatta A, Poutsma A, van Vegchel T, Oudejans CB. NEUROD1 acts in vitro as an upstream regulator of NEUROD2 in trophoblast cells. Biochim Biophys Acta 2004; 1676(1):96-103.

Last edited on: 19 September 2013
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