Carlijn Voermans PhD

Bone marrow microenvironment

Dept of Hematopoiesis

Adult hematopoietic stem and progenitor cells (HSPC) reside in the bone marrow (BM) in so-called niches. Mesenchymal stromal cells (MSC) are an important constituent of this bone marrow microenvironment where they support hematopoiesis via direct cell-cell interactions with hematopoietic stem- and progenitor cells, and by releasing soluble factors (such as Wnt and Slit proteins). However, the mechanism by which the microenvironment regulates hematopoiesis is not completely understood. In the group of Carlijn Voermans PhD the homeostatic and regenerative BM-environment are studied from a HSPC and MSC perspective with a focus on the interactions between the hematopoietic and stromal compartment.


Carlijn Voermans



Last edited on: 20 July 2016