Thesis Nigel Stapleton
On 21 February 2020 Nigel Stapleton defended his thesis 'To bind or not to bind: A study into FcRn interactions' at the University of Amsterdam
Promotor: Prof C Ellen van der Schoot MD PhD
Copromotor: Gestur Vidarsson PhD
Venue: Aula University of Amsterdam
Chapters
Chapter 1
General introduction
Chapter 2
Short half-life of human IgG3 due to competition for FcRn-mediated transport reveals its therapeutic potential
Chapter 3
On the perplexingly low rate of transport of IgG2 across the human placenta Abstract
Chapter 4
Human IgG lacking effector functions demonstrate lower FcRn-binding and reduced transplacental transport Abstract
Chapter 5
Reduced FcRn-mediated transcytosis of IgG2 due to a missing Glycine in its lower hinge Abstract
Chapter 6
FcRn: an IgG Receptor on Phagocytes with a Novel Role in Phagocytosis Abstract
Chapter 7
General discussion
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Download PhD thesis (university repository)