Profiles of Transfusion Recipients (PROTON2-study)
Information on blood recipients from 1995-2006 was collected in 20 Dutch hospitals to establish the PROTON dataset, containing 2.4 million transfusions and their recipients. Data were linked to mortality databases (GBA) and hospital discharge diagnoses databases (LMR) at Statistics Netherlands (CBS). The PROTON dataset encompasses 28% of the total blood use in the Netherlands.
In collaboration with Clinical Consultancy Services of the Sanquin Blood Bank, TTA started in 2011 with a program aiming at a continuous collect of data in all segments of the blood transfusion chain in order to monitor and optimize the blood transfusion chain. This project (PROTON2) was a logical prolongation of the successful earlier PROTON project. Additional collaboration with the EMGO+ institute (Amsterdam) and the Jon J van Rood Center for Clinical Transfusion Research (Leiden) will over the next few years lead to a national research database with data on the whole blood transfusion chain. This central data warehouse will allow for answering a range of research questions for various stakeholders. The PROTON2 database will allow:
- (Inter)national benchmarking of hospitals on blood use characteristics (e.g. blood use per patient subgroup, outdating, shelf life, transfusion triggers). This can support managerial and/or logistic optimization and the development of guidelines on optimal blood use.
- Trend analysis on clinical blood use among different patient subgroups and age distributions as well as changing indications and transfusion triggers which can be used to estimate future blood demand (optimal blood supply).
- Quantitative analyses of (adverse) clinical outcomes and transfusion recipient survival in relation to various determinants in donor, product and/or production and recipient characteristics (optimal blood safety).
The relationship between age and diagnosis of red blood cell recipients.
- Borkent-Raven BA. The PROTON study: Profiles of transfusion recipients in the Netherlands. PhD Thesis November 9, 2010 University Utrecht, ISBN 978-90-393-5407-0 (pdf).
- Borkent-Raven BA, Janssen MP, van der Poel CL, Schaasberg WP, Bonsel GJ, van Hout BA. Survival after transfusion in the Netherlands. Vox Sang 2011; 100(2):196-203.
- Borkent-Raven BA, Janssen MP, van der Poel CL. Demographic changes and predicting the blood supply and demand in the Netherlands. Transfusion 2010; 50(11):2455-60.
- Borkent-Raven BA, Janssen MP, van der Poel CL, Schaasberg WP, Bonsel WP, and van Hout BA. The PROTON study: profiles of blood product transfusion recipients in the Netherlands. Vox Sang 2010; 99(1):54-64.