Modeling Infections in the Transfusion Chain (MITCH-study)
The aim of the MITCH study (Modeling emerging Infections in the Transfusion CHain), which started in 2010, is to provide a decision support model that quantifies decision elements that play a role in the decision making with respect to blood safety measures to be taken in case of outbreaks of emerging infectious diseases (EIDs). For this purpose a general mathematical modeling tool for assessing the risks from EIDs in the transfusion chain was developed. The model was translated into a web-based tool, named EUFRAT, in collaboration with the European Centre for Disease Prevention and Control (ECDC). The EUFRAT tool supports timely and rational decisions in case of future epidemiological spread or outbreaks of EIDs. With the tool, which in future will be made available to European Member states by ECDC, the risks from a variety of EIDs, which differ in biological properties and their respective impact on the transfusion chain, can be modeled.
The MITCH project is a collaboration between TTA and the Utrecht Center for Infection Dynamics (UCID), which is a center of excellence for interdisciplinary research in infectious diseases. Such collaboration allows for integration of expertise on EID modeling and blood transfusion.
In addition to the development of a generic model to analyze the risk of EID transmission through the blood transfusion chain, within the MITCH project also risk prioritization of EIDs with respect to (uncertain) disease characteristics, estimating the risk of various past EID outbreaks, and an analysis of the transfusion transmission risk from Dutch traveling donors are undertaken.
- Oei W, Janssen MP, van der Poel CL, van Steenbergen JE, Rehmet S, Kretzschmar ME. Modeling the transmission risk of emerging infectious diseases through blood transfusion. Transfusion 2012 Nov 1. [Epub ahead of print].
- EUFRAT web-tool