Regulatory antibodies & Biologicals

Group leader: Theo Rispens PhD

Immunoglobulins are key players in immune responses against many pathogens, but also against non-infectious agents such as allergens or therapeutic biomolecules. Depending on the type of antibody, their effects may range from immune activation or target neutralization, to down-modulation of the immune response. It is only partially understood how the many functions of immunoglobulins relate to their structural variability (including subclass, glycosylation profile, and hinge isomers). In a therapeutic setting, antibodies are used to treat a variety of disorders. Stability and composition are major factors influencing efficacy and may lead to adverse effects such as hypersensitivity reactions. For monoclonal antibodies, immunogenicity is increasingly being recognized as a potential threat. Our main theme is to understand the structure-function relationships of different human immunoglobulins. In this context, we focus on three, interconnected topics:

Structural and functional properties of human IgG4

Structure-function relationships with intravenous immunoglobulin (IVIg)

Immunogenicity of biologicals

Last edited on: 22 April 2013