News & Highlights
Two VENI grants for researchers from the department of Hematopoiesis
|Regina Stark en Pleun Hombrink, each received a prestigious VENI-grant. Less than 15% of the submitted proposals could be granted. The VENI grants provides highly promising young scientists with the opportunity to further elaborate their own ideas during a period of three years.
Regina received the grant for her research proposal ‘Immune cells under attack’. Regina: “The immune system is essential to keep us healthy. During the attack by pathogens the inflammation generated by the fighting immune system also causes collateral damage and restructures the tissue. I will investigate how this inflammation influences the local defense function of immune cells in tissues.”
Pleun received his grant for the research proposal ‘Local support to lung-resident memory T cell function: The importance of location’. Pleun: “Lungs are protected against pathogens by distinct CD8+ T cell populations with unique functional and phenotypic properties. The molecular mechanisms underlying their precise localization, function and maintenance are unknown. I will combine unbiased genomic analysis of single cells with immunohistochemistry to investigate interactions between T cells and diverse microenvironments.”
Battling infections using trapped immune cells
|Research has revealed how immune cells stay trapped within the lungs. This could help improve the development of better vaccines, which focus on generating local immunity. Most immune cells in the blood travel through the body, searching for inflamed tissue. However, the lungs contain very effective immune cells locally. These local habitants are specialized in eliminating viruses and bacteria that reside within the lungs. Scientists of Sanquin and their Australian colleagues have shown how these cells stay trapped within the lungs. They published this work in Science on 22 April 2016.
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Best oral presentation at the 9th annual meeting of the DSSCR for Marieke Goedhart
|PhD student Marieke Goedhart won one of the three awards for best oral presentation at the 9th annual meeting of the DSSCR (Dutch Society for Stem Cell Research), held on 22 April 2016 in Utrecht. She presented her research entitled 'Chronic exposure to Interferon-gamma remodels the bone marrow stromal compartment'. With this research, she showed that bone marrow mesenchymal stromal cells (MSC) are significantly reduced after chronic exposure to the pro-inflammatory cytokine IFN-gamma. MSC in the bone marrow are supporting cells for hematopoietic stem cells (HSC) and keep these valuable stem cells quiescent, which is critical for maintaining a lifelong supply of blood cells. Marieke found that a loss of supporting MSC upon IFN-gamma exposure was accompanied by a loss of quiescent HSC, which may eventually lead to exhaustion of the hematopoietic compartment. This research thus provides valuable insights in the underlying mechanisms of inflammation induced anemia and bone marrow failure.|
MEIS1 regulates early erythroid and megakaryocytic cell fate
|We are excited to see that the graphical abstract of the paper by Sabrina Zeddies and her colleagues was selected for the cover of Haematologica.
In this publication, we describe how the transcription factor MEIS1 is balancing cell differentiation towards the megakaryocytic-erythroid lineage during hematopoiesis. Generating a sufficient number of hematopoietic progenitor cells is important to ensure proper amounts of blood cells in the periphery. The image shows a slightly tipped scale due to the expression of MEIS1 in common myeloid progenitor cells (blue cell). MEIS1 expression induces differentiation towards a megakaryocyte-erythroid fate, thereby increasing numbers of these progenitors (red cells). At the same time, MEIS1 expression inhibits the cells from becoming granulocyte-monocyte progenitors (green cells).
If you want to find out how we discovered this new, exciting role of MEIS1, read the full paper.
Read Marieke von Lindern's Research blog on Sanquin Talks
Hematopoietic stem cells walk on a narrow balance between leukemia and aging
|The secretary Anita Engels celebrated today (April 10th) her 12,5 years jubilee. She is the pivot of the departments IHE and HEP|
Thesis Melania Balzarolo
On 4 September 2013 Melania Balzarolo defended her thesis 'On the TRAIL of innate immune responses. Plasmacytoid Dendritic Cells and beyond' at the University of Amsterdam.
Promotor: Prof JP Medema PhD
Co-promotor: MC Wolkers PhD
Last edited on: 28 July 2017