Hematopoiesis is the process by which mature peripheral blood cells are formed from the hematopoietic stem cell (HSC). This process involves maintenance of the stem cell compartment, commitment of multipotent progenitors into the various lineages of the blood cell system, transient amplification of progenitor pools, and maturation to functional cells that are released into the circulation.
Sanquin is dedicated to develop and supply novel cellular products adapted to the future perspective of personalized medicine.
The Department of Hematopoiesis aims to be an expertise centre for basic research on survival, maintenance and lineage commitment of hematopoietic stem- and progenitor cells, and on the maturation of progenitors into functional peripheral blood cells. Whenever possible, we will use this knowledge for the development of novel cellular products that could be produced by the stem cell laboratory.
Within the department functions the Laboratory for Adaptive Immunity, whereas Hematopoiesis itself focuses on 5 major research lines:
|Bone marrow microenvironment (group leader: Carlijn Voermans)||T cell differentiation (group leader: Monika Wolkers)|
|Erythropoiesis (group leader: Emile van den Akker)||mRNA translation in erythropoiesis (group leader: Marieke von Lindern)|
|Megakaryocytopoiesis (group leader: Daphne Thijssen-Timmer)||T cells in transplantation & transfusion (group leader: Derk Amsen)|
|Resident T cell memory (group leader Klaas van Gisbergen)|
Highlights in 2012:
- LSBR fellowship granted to Emile van den Akker: From in vitro erythropoiesis to transfusion
- ZonMW TOP granted to Marieke von Lindern, collaboration with Sjaak Philipsen, dept. Cell Biology and Genetics, ErasmusMC, Rotterdam: Reactivation of fetal hemoglobin expression: functional analysis of candidate modifiers in vivo.
- Appointment as Associate Professorship (UHD) at the Dept. Hematology, AMC, UvA for Marieke von Lindern
- Opening Laboratory for Cellular Therapy by Carlijn Voermans and Daphne Thijssen-Timmer
The Adaptive Immunity Lab
The Adaptive Immunity Lab is part of the Department of Hematopoiesis and headed by Martijn Nolte. On one hand this lab has a research interest in the impact of immune activation on hematopoiesis, and on the other, in close collaboration with Prof Dr René van Lier, in the molecular mechanisms that underlie the formation of effector and memory T cells. As such, this lab operates at the crossroads of hematology and immunology and is fully integrated in the Department of Hematopoiesis.
|The impact of immune activation on hematopoiesis|
|The molecular mechanism of effector T cell formation|
Our department offers several internships for undergraduate students (University master students and HLO trainees). For more information and an overview of the current internships visit the student projects page.