Thesis Mariarosaria Miranda
On 6 November 2025 (10:00 AM) Mariarosaria Miranda expects to defend her PhD thesis 'A stranger no more: re-educating the immune system to FVIII in hemophilia A' at the University of Amsterdam.
Promotores
Prof JJ Voorberg PhD and Prof CJ Fijnvandraat MD PhD
Venue
Agnietenkapel, University of Amsterdam
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Abstract
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Chapters
Chapter 1
General Introduction
Chapter 2
FVIII peptides presented on HLA-DP and identification of an A3 domain peptide binding with high affinity to the commonly expressed HLA-DP4 abstract
Chapter 3
Exploring red blood cells as an antigen delivery system to modulate the immune response towards FVIII in hemophilia A abstract
Chapter 4
MHC class II presentation of FVIII-AnnexinA5 fusion proteins internalized by antigen presenting cells
Chapter 5
Reduced TNFα and IL-10 release by Pam3CSK4-stimulated dendritic cells by factor VIII immune complexes preferentially targeting FcʏRIIb
Chapter 6
The spectrum of neutralizing and non-neutralizing anti-FVIII antibodies in a nationwide cohort of 788 persons with hemophilia A abstract
Chapter 7
General discussion
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