Thesis Nigel Stapleton

On  21 February 2020 Nigel Stapleton defended his thesis 'To bind or not to bind: A study into FcRn interactions' at the University of Amsterdam

Promotor: Prof C Ellen van der Schoot MD PhD
Copromotor: Gestur Vidarsson PhD
Venue: Aula University of Amsterdam

Chapters

Chapter 1 
General introduction

Chapter 2
Short half-life of human IgG3 due to competition for FcRn-mediated transport reveals its therapeutic potential

Chapter 3
On the perplexingly low rate of transport of IgG2 across the human placenta Abstract

Chapter 4 
Human IgG lacking effector functions demonstrate lower FcRn-binding and reduced transplacental transport Abstract

Chapter 5
Reduced FcRn-mediated transcytosis of IgG2 due to a missing Glycine in its lower hinge Abstract

Chapter 6
FcRn: an IgG Receptor on Phagocytes with a Novel Role in Phagocytosis Abstract

Chapter 7
General discussion

Download

Download PhD thesis (university repository)