Thesis Maike van Hezel

On 28 February 2020 Sanquin researcher Maike van Hezel defended her thesis 'Effect of red cell transfusion on the host immune response in critically ill patients' at the University of Amsterdam

Promotores: Prof NP Juffermans MD PhD and Prof MJ Schultz MD PhD
Copomotor: R van Bruggen PhD
Venue: Agnietenkapel Universiteit van Amsterdam

Chapters

Chapter 1
General introduction and outline of this thesis

Chapter 2
The ability of extracellular vesicles to induce a pro- inflammatory host response.  Abstract

Chapter 3
Pathogenesis of non-antibody mediated transfusion- related acute lung injury from bench to bedside. Abstract

Chapter 4
Monocyte mediated activation of endothelial cells occurs only after binding to extracellular vesicles from red blood cell products, a process mediated by beta integrin. Abstract

Chapter 5
The effect of red blood cell transfusion on iron metabolism in critically ill patients.  Abstract

Chapter 6
Red blood cell transfusion results in adhesion of neutrophils in human endotoxemia and in critically ill patients with sepsis. Abstract

Chapter 7
The effect of red blood cell transfusion on platelet function in critically ill patients.  Abstract

Chapter 8
Transfusion of 35 days stored red blood cells does not alter lipopolysaccharide tolerance during human endotoxemia. Abstract

Chapter 9
Summary and discussion of this thesis

Download

Download thesis (university repository)