Younes (Y) Zoughlami
- Department
- Hematopoiesis
- y.zoughlami@sanquin.nl
- Training
2001-2007: Cell Biology and Immunology; Faculty of Biomedical sciences, University of Amsterdam 2006: Master thesis: A vicious relationship: the triangular relationship between biomaterials, bacteria and the immune system in biomaterial-associated infections
- Research interests
- Molecular mechanisms regulating chemokine and growth factor receptor function Ligand-dependent regulation of GPCR and tyrosine kinase growth factor receptor function has been widely studied, but the molecular mechanisms controlling receptor responsiveness prior to a stimulus are still poorly understood. In our group we identified the small GTPase Rac1 as a novel regulator of receptor function in steady state conditions. Our goal is to uncover the mechanisms by witch Rac1 exerts its function on the chemokine receptor CXCR4 and the growth factor receptor c-kit and to link my findings to hematopoiesis and infection.
- Technology
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- Pull-down and immunoprecipitation assays for analysis of protein-protein interactions
- Confocal microscopy and live cell imaging
- Transwell migration
- Cell culturing
- Western blotting
- Flowcytometry
- Resume
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2007-present PhD student at the department of Hematopoiesis, Sanquin Research, Amsterdam 2007 MSc degree in Biomedical Sciences, University of Amsterdam 2006-2007 Five months at the New York University, graduate school of Arts and Science (Master classes in fundamental biology en endocrinology) 2005-2006 Traineeship at the Department of Molecular Cell Biology and Immunology, VU medical center, Amsterdam (Characterization of the binding of human papilloma virus to dendritic cells) 2004-2005 Traineeship at the Department of Molecular Cell Biology, Sanquin Research, Amsterdam (The role of MAPKs in the regulation of CXCR4 surface expression and migration of hematopoietic stem cells) - Publications
- Sanquin publications
- Other publications
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de Witte L, Zoughlami Y , Aengeneyndt B, David G, van Kooyk Y, Gissmann L, Geijtenbeek TB. Binding of human papilloma virus L1 virus-like particles to dendritic cells is mediated through heparan sulfates and induces immune activation.
Immunobiology 2008; 212(9-10):679-91