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Timo (T) Rademakers PhD

Molecular Cell Biology

Molecular Biology, Cardiovascular Biology & Disease, Multiphoton Imaging


Plaque angiogenesis and lymphangiogenesis: can small vessels influence atherosclerosis?

Research interests

My research interest focuses on microvascular function in health and disease, combined with in vivo multiphoton imaging. At Sanquin, I am working on (further) defining the bone marrow vascular niche and the interactions of bone marrow endothelium with other bone marrow cell types. In vitro and in vivo characterisation of the bone marrow vascular niche, as well as in vivo imaging of microvascular function and stem cell grafting/ trafficking are key points of the current project. In addition, development of novel imaging approaches for (in vivo) multiphoton microscopy is one of my personal interest.

  • Cell culture
  • Immunohistochemistry/immunofluorescence
  • Spectral microscopic imaging
  • (In vivo) multiphoton microscopy
2014-present Post-doc fellow at the Dept of Molecular Cell Biology (group JD van Buul), Sanquin Research
2012-2013 Post-doctoral fellow at the Dept of Pathology (group EAL Biessen, CJ Peutz-Kootstra), Maastricht University
Subject: renal microvascular alterations upon hypertension and diabetes
2008-2012 PhD student at the Dept of Pathology (supervisors: EAL Biessen, MAMJ van Zandvoort, S Heeneman), Maastricht University
Thesis: Plaque angiogenesis and lymphangiogenesis: can small vessels influence atherosclerosis? (26 June 2013)
2006-2008 MSc Clinical Molecular Sciences, transnational University Limburg (tUL)/ Maastricht University
2003-2006 BSc Molecular Life Sciences, Maastricht University


Sanquin publications
Other publications

Schmitt MM, Megens RT, Zernecke A, Bidzhekov K, van den Akker NM, Rademakers T, van Zandvoort MA, Hackeng TM, Koenen RR, Weber C. Endothelial junctional adhesion molecule-a guides monocytes into flow-dependent predilection sites of atherosclerosis. Circulation 2014; 129(1):66-76.

Rademakers T, Douma K, Hackeng TM, Post MJ, Sluimer JC, Daemen MJ, Biessen EA, Heeneman S, van Zandvoort MA. Plaque-associated vasa vasorum in aged apolipoprotein E-deficient mice exhibit proatherogenic functional features in vivo. Arterioscler Thromb Vasc Biol 2013; 33(2):249-56.

Lievens D, Habets KL, Robertson A-K, Laouar Y, Winkels H, Rademakers T et al. Abrogated transforming growth factor beta receptor II (TGFβRII) signalling in dendritic cells promotes immune reactivity of T cells resulting in enhanced atherosclerosis. Eur Heart J 2013; 34(48):3717-27.

Nergiz-Unal R, Rademakers T, Cosemans JMEM, Heemskerk JWM. CD36 as a multiple-ligand signaling receptor in atherothrombosis. Cardiovasc Hematol Agents Med Chem 2011; 9(1):42–55.

Last edited on: 7 May 2014
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