Sabrina (S) Zeddies
Biology, Georg August-University Goettingen, Germany
The differentiation of astroglial cells in Geminin -deficient mouse mutants
Department Developmental Biology, Max-Planck-Institute for Biophysical Chemistry, Goettingen
- Research interests
Novel regulators of megakaryopoiesis and platelet formation.
Platelets are derived from mature megakaryocytes and a crucial component for hemostasis. Imbalances and alterations in the differentiation process of megakaryocytes can lead to disturbed platelet function and severe illnesses. The aim of this project is to characterize genes putatively regulated by the megakaryocyte-specific transcription factor MEIS1 and elucidate their function in megakaryopoiesis and platelet formation.
- Selection and culturing of CD34+ cells
- Lentiviral transduction of CD34+ cells
- Platelet isolation and activation
- Real-time PCR
- Western blotting
- Flow cytometry analysis
- Confocal microscopy
2009-present PhD-student, Department of Experimental Immunohematology, Sanquin Research, Amsterdam 2009 Graduation: Diploma-Biologist, Georg August-University, Goettingen, Germany 2004-2009 Research assistant, Department Expression Profiling / InVitro Pharmacology, DeveloGen AG, Goettingen, Germany 2002-2004 Technician, Departments InVitro Pharmacology, InVivo Pharmacology and Assay Development, DeveloGen AG, Goettingen, Germany
- Sanquin publications