Roel (RP) Gazendam
- Blood Cell Research
Medicine, Free University Amsterdam Medical Biology, Free University Amsterdam
- Research interests
- Innate immunity Opportunistic fungal infections, such as Candida albicans, in neutropenic patients have a high mortality rate. GTX neutrophils are administered with severe infections, also to overcome or prevent these opportunistic infections. However, how the neutrophil sense and signal in order to kill the 'fungal' pathogen is not fully understood. Recent observations and data indicate a role for the adaptor protein CARD9, which relays a signal from the Dectin pathway and can activate NFKb pathway. The aim of the project is to study the impact of intracellular sensing of pathogenic microbes in human neutrophils. Also, to investigate the regulation of the killing process of neutrophils will give a better rationale for the use of neutrophils for transfusions (GTX neutrophils) in neutropenic patients as adjuvant treatment.
- Western blotting
- Cloning techniques
- In vitro microbiocidal killing assays
2011-present PhD student at the Dept Blood Cell Research Sanquin Research/Pediatric immunology, Emma Children Hospital, AMC, Amsterdam 2010-2011 Peadiatric registrar, Sint Lucas Andreas Hospital, Amsterdam 2010 MD, Free UniversityAmsterdam 2008 MSc Medicine, Free University Amsterdam 2003-2004 Propedeuse Medical Biology, Free University Amsterdam
- Sanquin publications
- Other publications
Gazendam RP, van Vliet M, von Rosenstiel IA, van Zanten AP, Brandjes DP, Beijnen JH, Rotteveel J, Diamant M. Differential impact of impaired fasting glucose versus impaired glucose tolerance on cardiometabolic risk factors in multi-ethnic overweight/obese children. Eur J Pediatr 2011; 170(5):589-97.
Kneyber MC, Gazendam RP, Niessen HW, Kuiper JW, Dos Santos CC, Slutsky AS, Plötz FB. Mechanical ventilation during experimental sepsis increases deposition of advanced glycation end products and myocardial inflammation. Crit Care 2009; 13(3):R87.
Kneyber MC, Gazendam RP, Markhorst DG, Plötz FB. Length of storage of red blood cells does not affect outcome in critically ill children. Intensive Care Med 2009; 35(1):179-80.