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Marijke (MWA) Molenaar-de Backer PhD

Department
Blood-borne infections
E-mail
m.molenaar@sanquin.nl
LinkedIn
http://nl.linkedin.com/pub/marijke-molenaar/8/70a/334
Training

Biomedical sciences, Utrecht University

Thesis

‘Optimization of viral vector technology to study gene function in the hypothalamus’
Promoter: Prof RAH Adan PhD
3 juni 2010 - Utrecht University

Research interests
  • Molecular biology
  • Development of new (diagnostic) tests
  • Viral vector technology
Resume

Research visits
September-October 2007: Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, USA under supervision of Miguel Sena-Esteves

Publications
Sanquin publications
Other publications

De Backer MW, la Fleur SE, Adan RA. Both overexpression of agouti-related peptide or neuropeptide Y in the paraventricular nucleus or lateral hypothalamus induce obesity in a neuropeptide- and nucleus specific manner. Eur J Pharmacol 2011; 660:148-55.

De Backer MW, Brans MA, van Rozen AJ, van der Zwaal EM, Luijendijk MC, Garner KG, de Krom M, van Beekum O, la Fleur SE, Adan RA. Suppressor of cytokine signaling 3 knockdown in the mediobasal hypothalamus: counterintuitive effects on energy balance. J Mol Endocrinol 2010; 45(5):341-53.

De Backer MW, la Fleur SE, Brans MA, van Rozen AJ, Luijendijk MC, Merkestein M, Garner KM, van der Zwaal EM, Adan RA. Melanocortin receptor-mediated effects on obesity are distributed over specific hypothalamic regions. Int J Obes (Lond) 2011; 35 (5):629-641.

De Backer MW, Brans MA, Luijendijk MC, Garner KM, van den Heuvel DM, Pasterkamp RJ, Adan RA. Neuropeptide delivery to the brain: a von Willebrand factor signal peptide to direct neuropeptide secretion. BMC Neurosci 2010; 11:94.

De Backer MW, Fitzsimons CP, Brans MA, Luijendijk MC, Garner KM, Vreugdenhil E, Adan RA. An adeno-associated viral vector transduces the rat hypothalamus and amygdala more efficient than a lentiviral vector. BMC Neurosci. 2010; 11:81.

Jethwa PH, Warner A, Fowler MJ, Murphy M, de Backer MW, Adan RA, Barrett P, Brameld JM, Ebling FJ. Short-days induce weight loss in Siberian hamsters despite overexpression of the agouti-related peptide gene. J Neuroendocrinol 2010; 22(6):564-75.

De Backer MW, Brans MA, Luijendijk MC, Garner KM, Adan RA. Optimization of adeno-associated viral vector-mediated gene delivery to the hypothalamus. Hum Gene Ther 2010; 21(6):673-82.

Van Hooijdonk LW, Ichwan M, Dijkmans TF, Schouten TG, de Backer MW, Adan RA, Verbeek FJ, Vreugdenhil E, Fitzsimons CP. Lentivirus-mediated transgene delivery to the hippocampus reveals sub-field specific differences in expression. BMC Neurosci 2009; 10:2.

Last edited on: 20 April 2016
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