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Maartje (M) van den Biggelaar PhD

Department
Plasma Proteins
E-mail
m.vandenbiggelaar@sanquin.nl
LinkedIn
http://nl.linkedin.com/pub/maartje-van-den-biggelaar/6/500/6a
Training

Pharmaceutical Sciences, Utrecht University

Thesis

'Factor VIII trafficking to Weibel-Palade bodies'
2008 - Utrecht University

Research interests
The aim of my research is to develop innovative protein therapeutics for hemostatic disorders and my long lasting interest is in the biology of hemostatic proteins, with particular emphasis on von Willebrand factor and Factor VIII. The goals are (1) to understand the interaction of hemostatic proteins with endocytic receptors and (2) to identify communication networks between the hemostatic system and the vasculature. Unravelling these interactions and signaling networks is essential to develop rational approaches for the design of improved therapeutic coagulation proteins and to reveal novel targets for therapeutic intervention in hemostatic disorders.
Technology
  • Confocal laser scanning microscopy
  • Surface Plasmon Resonance analysis using Biacore
  • Recombinant protein production and immunoaffinity purification
  • Mass spectrometry-based quantitative phosphoproteomics
Resume

2013-present Scientist at the Dept of Plasma Proteins, Sanquin Research, Amsterdam
2011-2013 Visiting scientist, The Beatson Institute for Cancer Research,Glasgow, UK (S Zanivan PhD)
2007-2012 Postdoctoral Scientist at the Dept of Plasma Proteins, Sanquin Research, Amsterdam
2005 Laboratory of Genetics, SALK Institute, La Jolla, CA, USA (Prof Inder Verma PhD)
2002-2007 PhD student, Utrecht University

Honours and awards

2013 XXIVth International Society of Thrombosis and Haemostasis Congress, Amsterdam,  the Netherlands. Young Investigator Award
2009 XXIIth International Society of Thrombosis and Haemostasis Congress, Boston, USA. Young Investigator Award
2008 Gordon Research Conference, Proprotein processing, trafficking & secretion, New London, New Hampshire, USA
NIH grant
2007 49th American Society of Hematology Annual Meeting, Atlanta, Georgia, USA
ASH travel award
2005 XXth International Society of Thrombosis and Haemostasis Congress, Sydney, Australia
Young investigator award
2005 XXth International Society of Thrombosis and Haemostasis Congress, Sydney, Australia. NVTH-ISTH travel award

 

Publications
Sanquin publications
Last edited on: 21 April 2016
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