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Prof Lucien (LA) Aarden PhD

Department
Immunopathology
E-mail
l.aarden@sanquin.nl
Training

Biochemistry

Thesis

Immunology of DNA
1977 - University of Amsterdam

Research interests
Immune response to non-infectious agents. In man we analyse the B cell response to a number of therapeutic proteins such as monoclonal antibodies and cytokines. In addition and in cooperation with other parties we exploit animal models to verify our human data and to be able to manipulate the immunogenicity of proteins. Interaction of plasma proteins with cells in health and disease. We analyse which plasma proteins bind to live and dead cells. Lately our studies concentrate on HABP2, a serine protease that acts as a sensor for dead cells. We have observed strong activation of HABP2 in patients with a variety of diseases and try to unravel the physiological consequences of this activation.
Technology
  • Immunochemistry
  • Protein purification
  • Monoclonal antibodies
  • Immunoassays
  • Bioassays 
Resume
2002-presentStaff member of the Dept of Immunopathology, Sanquin Research, Amsterdam
1992-presentChair Molecular Immunology University of Amsterdam
1981–2002Head of Dept Auto Immune Diseases, CLB later Sanquin
1979–1981Postdoc at Dept of Auto Immune Diseases, CLB working on human IL1, IL2 and IL6
1977–1979Member Basel Institute for Immunology. Early studies on cytokines such as IL1 and IL2
1970-1977PhD training at Dept of Auto Immune Diseases, CLB and lab of Experimental Immunology, University of Amsterdam
Publications
Sanquin publications
Last edited on: 23 September 2013
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