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Gillian (G) Dekkers

Department
Experimental Immunohematology
E-mail
g.dekkers@sanquin.nl
LinkedIn
http://www.linkedin.com/pub/gillian-dekkers/46/681/438
Training

BSc Biology and MSc Molecular and Cellular Life Sciences, Utrecht University

Research interests

Antibody Glycosylation

Intravenous immunoglobulin (IVIg) contains the pooled immunoglobulin G (IgG) from the plasma of over a thousand donors. This polyvalent mixture of antibodies is used in a variety of diseases like immune deficiencies and autoimmune diseases.We are interested in the working mechanism of IVIg in the treatment of autoimmune diseases. It has been suggested that the glycosylation of antibodies has an influence on the affinity Fc-gamma-Receptors FcγR. Via these receptors the antibodies activate or inhibit immune effector functions, depending on the type of FcγR bound.In my project I will therefore produce recombinant antibodies of several subclasses of IgG, with different glycovariants. These can then be tested in model systems to define Antibody-FcγR binding and immune effects.

Resume
2013-presentPhD Student, Dept Experimental Immunohematology Sanquin Research
2011-2012MSc Literature Thesis
Title: ‘Overview of currently available HIV-1 functional antibody assays’
Institute of Tropical medicine, Antwerp, Belgium
2011MSc Internship at University College London, Division of Infection and Immunity, Wohl Virion Centre
Subject: ‘Direct library screening for new broadly HIV-1-neutralising llama VHH’
2010-2011MSc Internship at Utrecht University, Faculty of Science, Biology Department – Group: Cellular Architecture and Dynamics
Subject: ‘Bi-Specific VHH against HIV-1 and pIgR’
2006-2010Bachelor Biology, Utrecht University
Publications
Sanquin publications
Last edited on: 6 April 2016
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