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Dieke (DJ) van Rees

Department
Blood Cell Research
E-mail
d.vanrees@sanquin.nl
LinkedIn
https://nl.linkedin.com/pub/dieke-van-rees/33/123/568
Training

MSc Biomedical Sciences; Immunology and Infectious diseases

Research interests
This project aims to characterize SIRPα-CD47 interactions during antibody-mediated killing of tumor cells by neutrophils. The ubiquitously expressed CD47 is often upregulated on tumor cells, and serves as a ‘don’t kill me’ or signal for immune cells. Signal-regulatory protein (SIRP) α on myeloid cells, including macrophages and neutrophils, binds to CD47 and this interaction results in an inhibitory signal. We will explore how interfering with SIRPα-CD47 interactions promote antibody-mediated cancer cells destruction and we will also investigate the potential for therapeutic targeting of this interaction.
Technology
  • Flow cytometry
  • Confocal microscopy
  • Blood cell isolation
  • Phagocytosis assay
Resume
2015-present PhD student at Dept Blood Cell Research, Sanquin Research, Amsterdam, The Netherlands
2012-2014 Master Biomedical Sciences, VU, Amsterdam
2007-2011 Bachelor Life Sciences, Saxion, Deventer
Publications
Sanquin publications
Other publications


Last edited on: 27 July 2016
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