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Boris (BM) Hogema PhD

Department
Blood-borne infections
E-mail
b.hogema@sanquin.nl
LinkedIn
http://nl.linkedin.com/pub/boris-hogema/3/178/6a4
Training

Biochemistry and microbiology (University of Amsterdam)

Thesis

Catabolite repression by non-PTS substrates in Escherichia coli
Promotor: Prof K van Dam
1998

Research interests
Molecular biology Virus detection Epidemiology of blood-borne infections
Technology

Serological and molecular detection of infectious agents. Various biochemical techniques (related to protein-protein interactions)

Resume
2009-presentPostdoc at Dept of Blood-borne infections; staff at dept. of Viral Nucleic Acid Diagnostic Services (SDI)
2000-2009Postdoc at Dept of Biochemistry, Erasmus MC
1998-1999Postdoc at Oregon Health & Sciences University (Portland, Oregon, USA) and Free University
1993-1998PhD student
Publications
Sanquin publications
Other publications

Donowitz M, Singh S, Singh P, Chakraborty M, Chen Y, Murtazina R, Gucek M, Cole RN, Zachos NC, Salahuddin FF, Kovbasnjuk O, Broere N, Smalley-Freed WG, Reynolds AB, Hubbard AL, Seidler U, Weinman E, de Jonge HR, Hogema BM, Li X. Alterations in the proteome of the NHERF2 knockout mouse jejunal brush border membrane vesicles. Physiol Genomics 2011; 15:674-84.

Sarker R, Valkhoff VE, Zachos NC, Lin R, Cha B, Chen TE, Guggino S, Zizak M, de Jonge H, Hogema B, Donowitz M. NHERF1 and NHERF2 are necessary for multiple but usually separate aspects of basal and acute regulation of NHE3 activity. Am J Physiol Cell Physiol 2011; 300:C771-82.

Lin R, Murtazina R, Cha B, Chakraborty M, Sarker R, Chen TE, Lin Z, Hogema BM, de Jonge HR, Seidler U, Turner JR, Li X, Kovbasnjuk O, Donowitz M. D-glucose acts via sodium/glucose cotransporter 1 to increase NHE3 in mouse jejunal brush border by a Na+/H+ exchange regulatory factor 2-dependent process. Gastroenterology 2011; 140:560-71.

Donowitz M, Singh S, Singh P, Salahuddin FF, Chen Y, Chakraborty M, Murtazina R, Gucek M, Cole RN, Zachos NC, Kovbasnjuk O, Broere N, Smalley-Freed WG, Reynolds AB, Hubbard AL, Seidler U, Weinman E, de Jonge HR, Hogema BM, Li X. Alterations in the proteome of the NHERF1 knockout mouse jejunal brush border membrane vesicles. Physiol Genomics 2010; 42A(3):200-10.

Singh AK, Riederer B, Krabbenhöft A, Rausch B, Bonhagen J, Lehmann-Mühlenberg U, de Jonge HR, Donowitz M, Yun C, Weinman E, Kocher O, Hogema BM, Seidler U. Differentials role of NHERF1, NHERF2, and PDZK1 in regulation CFTR-mediated intestinal anion secretion in mice. J Clin Invest 2009; 119:540-550.

Donowitz M, Singh S, Salahuddin FF, Hogema BM, Chen Y, Gucek M, Cole RN, Ham A, Zachos NC, Kovbasnjuk O, Lapierre LA, Broere N, Goldenring J, deJonge H, Li X. Proteome of murine jejunal brush border membrane vesicles. J Proteome Res 2007; 6:4068-79.

Broere N, Hillesheim J, Tuo B, Jorna H, Houtsmuller AB, Shenolikar S, Weinman EJ, Donowitz M, Seidler U, de Jonge HR, Hogema BM. Cystic fibrosis transmembrane conductance regulator activation is reduced in the small intestine of Na+/H+ exchanger 3 regulatory factor 1 (NHERF-1) but not NHERF-2-deficient mice. J Biol Chem 2007; 282:37575-84.

Cha B, Kim JH, Hut H, Hogema BM, Nadarja J, Zizak M, Cavet M, Lee-Kwon W, Lohmann SM, Smolenski A, Tse CM, Yun C, de Jonge HR, Donowitz M. cGMP inhibition of Na+/H+ antiporter 3 (NHE3) requires PDZ domain adapter NHERF2, a broad specificity protein kinase G-anchoring protein. J Biol Chem 2005; 280:16642-50.

Verloo P, Kocken CH, Van der Wel A, Tilly BC, Hogema BM, Sinaasappel M, Thomas AW, De Jonge HR. Plasmodium falciparum-activated chloride channels are defective in erythrocytes from cystic fibrosis patients. J Biol Chem 2004; 279:10316-22.

Akaboshi S, Hogema BM, Novelletto A, Malaspina P, Salomons GS, Maropoulos GD, Jakobs C, Grompe M, Gibson KM. Mutational spectrum of the succinate semialdehyde dehydrogenase (ALDH5A1) gene and functional analysis of 27 novel disease-causing mutations in patients with SSADH deficiency. Hum Mutat 2003; 22:442-50.

Hogema BM, Gupta M, Senephansiri H, Burlingame TG, Taylor M, Jakobs C, Schutgens RB, Froestl W, Snead OC, Diaz-Arrastia R, Bottiglieri T, Grompe M, Gibson KM. Pharmacologic rescue of lethal seizures in mice deficient in succinate semialdehyde dehydrogenase. Nature Genet 2001; 29:212-6.

Hogema BM, Akaboshi S, Taylor M, Salomons GS, Jakobs C, Schutgens RB, Wilcken B, Worthington S, Maropoulos G, Grompe M, Gibson KM. Prenatal Diagnosis of Succinic Semialdehyde Dehydrogenase Deficiency: Increased Accuracy Employing DNA, Enzyme, and Metabolite Analyses. Mol Genet Metab 2001; 72:218-22.

Hogema BM, Arents JC, Bader R, Postma PW. Autoregulation of lactose uptake through the LacY permease by enzyme IIAGlc of the PTS in Escherichia coli K-12. Mol Microbiol 1999; 31:1825-33.

Hogema BM, Arents JC, Bader R, Eijkemans K, Yoshida H, Takahashi H, Aiba H, Postma PW. Inducer exclusion in Escherichia coli by non-PTS substrates: the role of the PEP to pyruvate ratio in determining the phosphorylation state of enzyme IIAGlc. Mol Microbiol 1998; 30:487-98.

Hogema BM, Arents JC, Bader R, Eijkemans K, Inada T, Aiba H, Postma PW. Inducer exclusion by glucose 6-phosphate in Escherichia coli. Mol Microbiol 1998; 28:755-65.

Hogema BM, Arents JC, Inada T, Aiba H, van Dam K, Postma PW. Catabolite repression by glucose 6-phosphate, gluconate and lactose in Escherichia coli. Mol Microbiol 1997; 24:857-67.

Last edited on: 20 September 2013
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