Methodological studies

Survival after transfusion (SAT) is an important variable to the QALY’s gained by blood safety interventions. TTA found marked differences in PROTON datasets between patient survival after the first transfusion versus the SAT for each individual component transfusion. Evaluating methods for estimating SAT yielded that the Kaplan-Meier method may provide correct estimates but confidence intervals are incorrect. Probabilistic risk models have outcomes with margins of uncertainty. Value of information (VOI) modeling allows systematic quantification of the expected gains of additional information by hypothetical research aimed at reduction of margins of uncertainty.