News Plasma Proteins
Recent publications
Stavenuiter F, Dienava-Verdoold I, Boon-Spijker MG, Brinkman HJ, Meijer AB, Mertens K. Factor Seven Activating Protease (FSAP): does it Activate Factor VII?
J Thromb Haemost 2012 Jan 11. doi: 10.1111/j.1538-7836.2012.04619.x. [Epub ahead of print]
Bloem E, Meems H, van den Biggelaar M, van der Zwaan C, Mertens K, Meijer AB. A mass spectrometry-assisted study reveals that lysine residues 1967 and 1968 have an opposite contribution to the stability of activated factor VIII.
Biol Chem 2012 Jan 3. [Epub ahead of print]
van Haren SD, Wroblewska A, Fischer K, Voorberg J, Herczenik E. Requirements for immune recognition and processing of factor VIII by antigen-presenting cells.
Blood Rev 2012; 26(1):43-9. Epub 2011 Oct 26.
Herczenik E, van Haren SD, Wroblewska A et al. Uptake of blood coagulation factor VIII by dendritic cells is mediated via its C1 domain. J Allergy Clin.Immunol 2011 Sep 29. [Epub ahead of print].
Thesis defense by Simon van Haren
| On 22 December 2011 Simon van Haren successfully defended his thesis entitled ‘Immune recognition and processing of blood coagulation factor VIII by antigen presenting cells’. Hemophilia A is an X-linked bleeding disorder caused by a deficiency of blood coagulation factor VIII. Frequent administration of factor VIII results in an immune response to administered factor VIII in approximately 25% of hemophilia patients with the severe form of the disease. Simon's work describes how FVIII is internalized by professional antigen presenting cells. His thesis also defines a region on factor VIII that is crucial for its internalization. Using a newly developed method Simon also showed which factor VIII-derived peptides are presented to CD4+ T cells on the surface of antigen presenting cells. Altogether, the research presented in his thesis may be utilized to develop novel therapeutic approaches that may limit the intrinsic immunogenicity of factor VIII. Simon has now accepted a position as a post-doc in the group of Ofer Levy PhD, Dept of Infectious Diseases, Children's Hospital Boston, Harvard Medical School where he will work on Toll-like receptors. More information |
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Two Abstract Achievement Awards for ASH 2011
| Two PhD students of our department have received an Abstract Achievement Award for the 2011 meeting of the American Society for Hematology in San Diego. Aleksandra Wroblewska received this prestigious award for her abstract on the uptake of blood coagulation factor VIII by antigen presenting cells. Aleksandra decribed a novel determinant on factor VIII which promotes its uptake by antigen presenting cells. Her findings may help to design improved therapies for treatment of patients with the X-linked bleeding disorder hemophilia A. Nicoletta Sorvillo received an award for her work on ADAMTS13. She identified a number of ADAMTS13-derived peptides that are presented on MHC class II to CD4+ T cells. This study greatly contributes to the etiology of acquired thrombotic thrombocytopenic purpura (TTP) Lydia Castro (PhD student) will present novel data on the binding of blood coagulation factor VIII to von Willebrand factor at the ASH2011 meeting. |
From left to right: Aleksandra Wroblewska, |
