Hematopoiesis
Hematopoiesis is the process by which mature peripheral blood cells are formed from the hematopoietic stem cell (HSC). This process involves maintenance of the stem cell compartment, commitment of multipotent progenitors into the various lineages of the blood cell system, transient amplification of progenitor pools, and maturation to functional cells that are released into the circulation.
Sanquin is dedicated to develop and supply novel cellular products adapted to the future perspective of personalized medicine.
The Department of Hematopoiesis aims to be an expertise centre for basic research on survival, maintenance and lineage commitment of hematopoietic stem- and progenitor cells, and on the maturation of progenitors into functional peripheral blood cells. Whenever possible, we will use this knowledge for the development of novel cellular products that could be produced by the stem cell laboratory.
Our department focuses on 5 major research lines.
Research lines | |
| Erythropoiesis | Megakaryocytopoiesis |
| Cellular therapies | Chemotaxis and chemorepulsion in HSC |
| T cell activation |
Laboratory for Adaptive Immunity
PIs: Martijn Nolte PhD and Prof René van Lier MD PhD
Besides the hematopoiesis lab, the department also includes the laboratory for adaptive immunity which holds 2 major research lines.
Research lines |
| The impact of immune activation on hematopoiesis |
| The molecular mechanism of effector T cell formation |
Student projects
Our department offers several internships for undergraduate students (University master students and HLO trainees). For more information and an overview of the current internships visit the student projects page.