Research program
Covering the complete spectrum of blood and blood transfusion research we aim to perform original work on not only basic and clinical, but also applied topics. As a consequence our research departments deal with a complementary range of subjects including fundamental biology and biochemistry of blood cells and plasma proteins, hematopoiesis, immunohematology, coagulation, Immunopathology, blood-borne infections, blood transfusion technology, transfusion monitoring, transfusion medicine, and donor studies. Also Product- and process development is part of the research portfolio. However product and procesdevelopment in a more strict meaning takes place within the divisions, and not within Sanquin Research.
Department |
Priciple Investigator |
Research group |
Research line |
| Blood-borne Infections | Prof Hans L Zaaijer MD PhD | Blood-borne Infections | Q-fever among blood donors |
| HEV-infection and blood safety | |||
| Residual risk | |||
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| Blood Cell Research | Timo K van den Berg PhD | Phagocyte Laboratory | Phagocytes |
| Erythrocytes | |||
| Platelets | |||
| Dirk de Korte PhD | Blood Transfusion Technology | Improving materials and methods for storage of blood components | |
| Bacterial safety of blood products | |||
| Pathogen reduction of cellular blood products | |||
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| Donor Studies | Wim LAM de Kort MD PhD | Donor Studies | Donor recruitment and retention |
| Donor characteristics and donor referrals | |||
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| Experimental Immunohematology | Prof C Ellen van der Schoot MD PhD | Experimental Immunohematology | Immune responses to blood group antigens |
| Humoral immune response | |||
| Minimal residual disease detection in childhood cancers | |||
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| Hematopoiesis | Martijn Nolte PhD Prof René AW van Lier MD PhD | Adaptive Immunity | Adaptive immunity |
| Marieke von Lindern PhD | Hematopoiesis | Erythropoiesis | |
| Cellular therapies | |||
| Megakaryopoiesis | |||
| Chemotaxis and chemorepulsion in hematopoietic (stem) cells | |||
| T cell activation | |||
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| Immunopathology | Prof Lucien A Aarden PhD | Autoimmune Diseases | Inflammation |
| Immunogenicity of biologicals | |||
| Immunochemistry | |||
| Prof S Marieke van Ham PhD | Immunopathology | Immune regulation by B cells | |
| Immune modulation by Dendritic cells | |||
| Immune regulation by Granzyme A and Granzyme escape mechanisms | |||
| Immune regulation by C1 esterase inhibitor | |||
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| Molecular Cell Biology | Prof Peter L Hordijk PhD | Molecular Cell Biology | Rho GTPase signaling in cell adhesion and migration |
| Endothelial cell signaling at the plasma membrane and at endosomes | |||
| Rho GTPase regulation and function in leukocyte transendothelial migration | |||
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| Plasma Proteins | Prof Koen Mertens PhD | Plasma Proteins | Structure and function of coagulation factors |
| Cellular receptors involved in the uptake of coagulation factors | |||
| Proteomics and biomolecular mass spectrometry of hemostatic proteins | |||
| Innovation of diagnostics of thrombotic and hemostatic disorders | |||
| Jan J Voorberg PhD | Cellular Hemostasis | Biosyntesis of von Willebrand factor | |
| Immune response to hemostatic proteins | |||
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| Transfusion Medicine | Anske (J)G van der Bom MD PhD Jaap Jan Zwaginga MD PhD | Sanquin-LUMC Jon J van Rood center for clinical transfusion research | Randomized clinical trials |
| Observational studies | |||
| Red blood cell antigen immunization | |||
| Umbilical cord | |||
| Transfusion related immunomodulation | |||
| Translational research | |||
| Prof Dick J van Rhenen | Randomized clinical trials | ||
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| Transfuson Monitoring | Janny de Wildt-Eggen PhD | Improvement of storage of blood products | |
| Development of new products | |||
| Transfusion monitoring | |||
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| Transfusion Technology Assessment | Cees L van der Poel MD PhD | Sanquin-Julius Centre transfusion technology assessment unit | Transfusion technology assessment |
For Product and Services departments click here.