Project leader: Martin Smid MD PhD
Sanquin performs therapeutic plasma apheresis and stem cell collection in a number of hospitals. A large number is done for the Department of Nephrology of the UMCG. To add to improvement of performance and define indications, the method used to estimate the plasma volume was evaluated, as was the indication for plasma apheresis in atypical HUS.
Further, the effect of therapeutic apheresis in therapy resistant ANCA associated vasculitis was evaluated.
Clinical project: enhancing quality of autologous stem cell products in cooperation with UMCG’s Department of Hematology
This project aims at enhancing the quality and quantity of stem cells in autologous transplants and was executed with financial support from Tekke Huizinga Fonds. Over the years Sanquin performed stem cell collection and processed the autologous products, executed in close cooperation with the University Medical Centre Groningen (UMCG) which treats and transplants the patients.
Project leader: Margriet Dijkstra-Tiekstra PhD
Donor Characteristics versus Patient Characteristics
In this study donor data (age, gender, blood group and Hemoglobine before donation) were coupled to transfusion data (red cells) of the hemoto oncological department of one hospital. It was studied whether these donor data could influence transfusion outcome (delta HB and transfusion interval). It appeared that age and gender of the donor did not influence transfusion, but that donor blood group influenced transfusion interval and HB prior to donation influenced delta HB. In future studies we want to look to data from other hospital departments, data from other hospitals and to a broader donor data set.
Dijkstra-Tiekstra MJ, van de Watering LMG, Rondeel JMM, Slomp J, de Wildt-Eggen J. Implementation of a new platelet pooling system for platelet concentrates led to a higher corrected count increment after transfusion: a comparative observational study of platelet concentrates before and after implementation. Transfus Med 2014; 24(2):99-104.
Zeinali Lathori A, Zaaijer HL, Smid WM. Positive HBV-NAT in a blood donor 11 years after HBV vaccination. Transfus Med 2013; 24(1):62-3.
Dijkstra-Tiekstra MJ, Rondeel JM, Slomp J, Smid WM, de Wildt-Eggen J. A positive effect of immune suppression on corrected count increment after platelet transfusion at 1 but not at 24h. Transfus Apher Sci 2013; 49(2):189-92.
Smid WM, Buining R, de Kort W. Blood supply management: experience and recommendations from the Netherlands. ISBT Science Series 2013; 8(1):50-3.
van der Wijk J, Smid WM, Seelen MA, van de Kar NC, Offerman JJ, van Son WJ. Renal transplantation in patients with atypical haemolytic uraemic syndrome: a tailor made approach is necessary. Neth J Med 2011; 69(6):279-80.
Woolthuis C, Agool A, Olthof S, Slart RH, Huls G, Smid WM, Schuringa JJ, Vellenga E Auto-SCT induces a phenotypic shift from CMP to GMP progenitors, reduces clonogenic potential and enhances in vitro and in vivo cycling activity defined by (18)F-FLT PET scanning. Bone Marrow Transplant 2011; 46(1):110-5.