PI: Marieke von Lindern PhD 

Hematopoiesis is the process by which mature peripheral blood cells are formed from the hematopoietic stem cell (HSC). This process involves maintenance of the stem cell compartment, commitment of multipotent progenitors into the various lineages of the blood cell system, transient amplification of progenitor pools, and maturation to functional cells that are released into the circulation.

Sanquin is dedicated to develop and supply novel cellular products adapted to the future perspective of personalized medicine.

The Department of Hematopoiesis aims to be an expertise centre for basic research on survival, maintenance and lineage commitment of hematopoietic stem- and progenitor cells, and on the maturation of progenitors into functional peripheral blood cells. Whenever possible, we will use this knowledge for the development of novel cellular products that could be produced by the stem cell laboratory.

Within the department functions the Laboratory for Adaptive Immunity, whereas Hematopoiesis itself focuses on 5 major research lines:

Research lines

Bone marrow microenvironment Carlijn Voermans2 (group leader: Carlijn Voermans) T cell differentiation Monika Wolkers 40 pixels (group leader: Monika Wolkers)
Erythropoiesis Emile van den Akker (group leader: Emile van den Akker) mRNA translation in erythropoiesis Marieke von Lindern(group leader: Marieke von Lindern)
Megakaryocytopoiesis Daphne-Thijssen-Timmer (group leader: Daphne Thijssen-Timmer) T cells in transplantation & transfusionDerk Amsen (group leader: Derk Amsen)
Resident T cell memory Klaas van Gisbergen 40 pixels (group leader Klaas van Gisbergen)  


Highlights in 2012:


The Adaptive Immunity Lab 

PIs: Martijn Nolte PhD and Prof René van Lier MD PhD

The Adaptive Immunity Lab is part of the Department of Hematopoiesis and headed by Martijn Nolte. On one hand this lab has a research interest in the impact of immune activation on hematopoiesis, and on the other, in close collaboration with Prof Dr René van Lier, in the molecular mechanisms that underlie the formation of effector and memory T cells. As such, this lab operates at the crossroads of hematology and immunology and is fully integrated in the Department of Hematopoiesis.

Research lines

The impact of immune activation on hematopoiesis Martijn Nolte 40 pixels
The molecular mechanism of effector T cell formation Martijn Nolte 40 pixels Rene van Lier

Student projects

Our department offers several internships for undergraduate students (University master students and HLO trainees). For more information and an overview of the current internships visit the student projects page.

Last edited on: 2 September 2016