Clinical Transfusion Research
The patient oriented research of Sanquin Blood Supply is coordinated at the Center for Clinical Transfusion Research (CCTR). The CCTR encompasses patient oriented research activities of the research department of Clinical Transfusion Research, head Johanna (Anske) van der Bom and of the unit Transfusion Medicine, head Marian van Kraaij. Research activities in collaboration with the Leiden University Medical Center are hosted by the joint Sanquin - Leiden University Medical Center Jon J van Rood Center for Clinical Transfusion Research, principle investigators Jaap Jan Zwaginga, Johanna (Anske) van der Bom and Masja de Haas.
The mission of the Center for Clinical Transfusion Research is to produce and distribute the best quality knowledge on the practice of transfusion medicine and by doing so to optimize the care for the individual patient that needs blood products or cell therapy.
Three lines of research are distinguished:
- Bleeding & anemia: encompassing prevention, treatment and prediction of bleeding and anemia in various clinical situations, among others obstetric hemorrhage, cardiothoracic surgery, orthopedic surgery, hemato-oncology, critically ill patients and neonates; with special emphasis on the optimization of transfusion treatment strategies according to individual patient profiles;
- Clinical cellular therapy: including efficacy and safety of emerging cellular therapies;
- Side effect of transfusion: including red cell alloimmunisation, transfusion related acute lung injury, allergic reactions and storage effects.
Productivity and quality of our research is warranted by substantial emphasis on research methods of applied transfusion research and by solid collaborations with other transfusion medicine scientists and clinicians who are active throughout the transfusion chain establishing translational synergy between basic research and clinical practice.
Ongoing and recently finished projects
|> ExpEryence||> Plasma|
|ATTACH||> Platelet Safety Program|
|Match||> TOMAAT & LISBOA|
|> Universal platelet donors|
Educationals on Transfusion Epidemiology
Middelburg RA, Wiersum-Osselton JC, van de Watering LM, van der Bom JG. Observational etiologic research: Part 1-The etiologic research question: it requires DATA. Transfusion. 2013 Sep 30 [Epub ahead of print]
Middelburg RA, Wiersum-Osselton JC, van de Watering LM, van der Bom JG. Observational etiologic research: Part 2-Effect measures in etiologic research. Transfusion. 2013 Sep 30 [Epub ahead of print]
Middelburg RA, Wiersum-Osselton JC, van de Watering LM, van der Bom JG. Observational etiologic research: Part 3-Case-control studies: it's all about the source population. Transfusion. 2013 Sep 30 [Epub ahead of print]
Middelburg RA, Wiersum-Osselton JC, van de Watering LM, van der Bom JG. Observational etiologic research: Part 4-Matching in case-control studies: almost always a bad idea. Transfusion. 2013 Sep 30 [Epub ahead of print]
Zalpuri S, Middelburg RA, van de Watering L, Vamvakas E, Zwaginga JJ, van der Bom JG. Association vs causality in transfusion medicine: understanding multivariable analysis in prediction vs etiologic research. Transfus Med Rev 2013; 27(2):74-81.
Middelburg RA, le Cessie S, Briët E, Vandenbroucke JP, van der Bom JG. A solution to the problem of studying blood donor-related risk factors when patients have received multiple transfusions. Transfusion 2010; 50(9):1959-66.
Middelburg RA, van de Watering LM, van der Bom JG. Blood transfusions: good or bad? Confounding by indication, an underestimated problem in clinical transfusion research. Transfusion 2010; 50(6):1181-3.
Van de Watering L; Biomedical Excellence for Safer Transfusion (BEST) Collaborative. Pitfalls in the current published observational literature on the effects of red blood cell storage. Transfusion. 2011 Aug;51(8):1847-54.