Literature

Cell therapy

• AH Bakker, et al. (2008) Conditional MHC class I ligands and peptide exchange technology for the human MHC gene products HLA-A1, -A3, -A11, and -B7. PNAS 105: 3825-3830 
• R Casalegno-Garduño, et al. (2010) Multimer technologies for detection and adoptive transfer of antigen-specific T cells. Cancer Immunology, Immunotherapy 59: 195-202  
• L Hershkovitz, et al. (2010) Focus on adoptive T cell transfer trials in melanoma. Clin Dev Immunol. 2010: 260267  
• P Hombrink, et al. (2011) High-Throughput Identification of Potential Minor Histocompatibility Antigens by MHC Tetramer-Based Screening: Feasibility and Limitations. PLoS ONE 6: e22523  
• M Knabel, et al. (2002) Reversible MHC multimer staining for functional isolation of T-cell populations and effective adoptive transfer. Nature Medicine 8: 631-637  
• WA Marijt, et al. (2003) Hematopoiesis-restricted minor histocompatibility antigens HA-1- or HA-2-specific T cells can induce complete remissions of relapsed leukemia. Proc Natl Acad Sci USA 100: 2742-2747  
• J Neudorfer, et al. (2007) Reversible HLA multimers (Streptamer) for the isolation of human cytotoxic T lymphocytes functionally active against tumor- and virus-derived antigens. JIM 320: 119-131  
• K Palucka, H Ueno, J Banchereau. (2011) Recent developments in cancer vaccines. J Immunol 186: 1325-1331  
• C Roddie, KS Peggs. (2011) Donor lymphocyte infusion following allogeneic hematopoietic stem cell transplantation. Expert Opin Biol Ther. 11: 473-487  
• A Schmitt, et al. (2011) Adoptive transfer and selective reconstitution of streptamer-selected cytomegalovirus-specific CD8+ T cells leads to virus clearance in patients after allogeneic peripheral blood stem cell transplantation. Transfusion ;51:591-599  
• M Toebes, et al. (2006) Design and use of conditional MHC class I ligands.
  Nature Medicine 12:246-251  
• J Weber, et al. (2011) Immunotherapy Task Force of the NCI Investigational Drug Steering Committee. White paper on adoptive cell therapy for cancer with tumor-infiltrating lymphocytes: a report of the CTEP subcommittee on adoptive cell therapy. Clin Cancer Res 17: 1664-1673  

MHC multimers

General

• JD Altman et al. (1996) Phenotypic Analysis of Antigen-Specific T Lymphocytes. Science 274: 94-96  
• DN Garboczi et al. (1992) HLA-A2 peptide complexes: Refolding and crystallization of molecules expressed in E. coli and complexed with single antigenic peptides. Proc Natl Acad Sci USA 89: 3429-3433
• PJ Schatz, et al. (1993) Use of peptide libraries to map the substrate specificity of a peptide-modifying enzyme: a 13 residue consensus peptide specifies biotinylation in Escherichia coli Biotechnology 13: 1 138-1143
• K Schepers et al. (2002) Differential kinetics of antigen-specific CD4+ and CD8+ T-cell responses in the regression of retrovirus-induced sarcomas. J Immunol 169: 3191-3199

Pelimers

• MHMGM den Brok, et al. (2006) Efficient loading of dendritic cells following cryo and radiofrequency ablation in combination with immune modulation induces anti-tumour immunity. Br J of Cancer (2006) 95, 896–905
• SR Hadrup et al. (2009) High-Throughput T-Cell Epitope Discovery Through MHC Peptide Exchange. Methods in Molecular Biology 524: 383-405
• D Pokornáa et al. (2009) Vaccination with human papillomavirus type 16-derived peptides using a tattoo device. Vaccine 27: 3519-3529
• I Schulte et al. (2011) Characterization of CD8+ T-cell response in acute and resolved hepatitis A virus infection. J of Hepatology 54: 201-208
• M Toebes et al. (2009) Generation of Peptide MHC Class I Monomers and Multimers Through Ligand Exchange. Current Protocols in Immunology 87:18.16.1–18.16.20

Strep tamer ® technology

• R. Casalegno-Garduño et al. (2010) Multimer technologies for detection and adoptive transfer of antigen-specific T cells. Cancer Immunology, Immunotherapy 59: 195-202  
• M. Knabelet al. (2002) Reversible MHC multimer staining for functional isolation of T-cell populations and effective adoptive transfer. Nature Medicine 8: 631-637  
• J. Neudorfer et al. (2007) Reversible HLA multimers (Streptamer) for the isolation of human cytotoxic T lymphocytes functionally active against tumor- and virus-derived antigens. JIM 320: 119-131
• J. Yao et al. (2008) Multimer staining of cytomegalovirus phosphoprotein 65-specific T cells for diagnosis and therapeutic purposes: A comparative study. CID 46, e96-105  

UV-induced peptide exchange and Combinatorial Coding  

• AH Bakker et al. (2008) Conditional MHC class I ligands and peptide exchange technology for the human MHC gene products HLA-A1, -A3, -A11, and -B7. Proc Natl Acad Sci USA 105: 3825-3830
• PH Celie et al. (2009) UV-induced ligand exchange in MHC class I protein crystals. J Am Chem Soc 131: 12298-12304  
• EM Frickel et al. (2008) Parasite stage–specific recognition of endogenous Toxoplasma gondii–derived CD8+ T cell epitopes. J Infectious Diseases 198: 1625-1633  
• S Gredmark-Russ et al. (2008) The CD8 T cell response against murine Gammaherpesvirus 68 is directed toward a broad repertoire of epitopes from both early and late antigens. J Virol 82: 12205–12212  
• GM Grotenbreg et al. (2008) Discovery of CD8+ T cell epitopes in Chlamydia trachomatis infection through use of caged class I MHC tetramers. Proc Natl Acad Sci USA 105: 3831-3836  
• AR Hadrup et al. (2009) Parallel detection of antigen-specific T cell responses by multidimensional encoding of MHC multimers. Nature Methods 6: 520-526  
• SR Hadrup et al. (2009) High-throughput T cell epitope discovery through MHC peptide exchange. Methods Mol Biol 524: 383-405  
• SR Hadrup and TN Schumacher. (2010) MHC-based detection of antigen-specific CD8+ T cell responses. Cancer Immunol Immunother 59: 1425-1433  
• B Rodenko et al. (2006) Generation of peptide–MHC class I complexes through UV-mediated ligand exchange. Nature Protocols 1: 1120-1132  
• I Schulte et al. (2011) Characterization of CD8+ T cell response in acute and resolved hepatitis A virus infection. J Hepatol 54: 201-208  
• M Toebes et al. (2009) Generation of Peptide MHC Class I Monomers and Multimers Through Ligand Exchange. Current Protocols in Immunology 87:18.16.1–18.16.20  
• JH Velthuis et al. (2010) Simultaneous detection of circulating autoreactive CD8+ T cells specific for different islet cell-associated epitopes using combinatorial MHC-multimers. Diabetes 59: 1721-1730  
• M Toebes et al. (2006) Design and use of conditional MHC class I ligands. Nature Med 12: 246-251