T cell immunomonitoring for an innovative way of treatment
Sanquin has done outstanding research for many years regarding human leukocytes and cellular immunology. We combine this with high-quality diagnostic laboratory services and extensive experience in the production of immunological reagents.
Products
| MHC multimers for antigen-specific T cell detection and isolation |
| Recombinant proteins for all kind of research applications |
| UV-induced peptide exchange technology for high-throughput screening of peptide binding to the MHC class I complex |
| Combinatorial Coding enables fast finding of the right T cells |
| T cell Epitope Service testing Particularly interesting for pharmaceutical companies that need immunogenicity testing for e.g. vaccine development and cancer treatment |
New developments
Recently our product portfolio has been extended with the newly developed UV-induced peptide exchange technology for high-throughput screening of peptide binding to the MHC class I complex, and Combinatorial Coding that enables fast finding of the right T cells.
With combinatorial coding, a maximum of immunogenic epitopes can be tested with a minimum of patient blood.
Service testing
UV-induced peptide exchange and Combinatorial Coding are offered as T cell Epitope Test Service. These techniques are of particular interest for pharmaceutical companies that need immunogenicity testing for e.g. vaccine development and cancer treatment.
Background
In 1999, divisions Reagents / Research in Amsterdam and the Netherlands Cancer Institute (NKI) in Amsterdam launched an MHC-multimer core facility at Sanquin’s premises. This has resulted in a fast expanding product range for T cell research.
More information
- Read recent publications related to this subject.
- Watch the animation on new techniques for T cell immunomonitoring: