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PhD theses from 2002 - present
PhD theses 2010
PhD theses 2009
PhD theses 2008
PhD theses 2007
PhD theses 2006
PhD theses 2005
PhD theses 2004
PhD theses 2003
PhD theses 2002



PhD theses 2010
  • Fabian Stavenuiter
    23 June 2010
    'Factor Seven Activating Protease: in Search of a Physiological Role'
    Promotor: pProf. dr. K. Mertens
    Co-promotor: Dr. A.B. Meijer
    University of Utrecht
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  • Agata Drewniak
    1 June 2010
    ‘Supplying the demand for granylocytes: Function and gene expression profile of mobilized neutrophils’
    Promotor: Prof. dr. T.W. Kuijpers and prof. dr. D. Roos
    University of Amsterdam
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  • Laurence Trannoy
    12 May 2010
    'Pathogen inactivation in cellular blood products by photodynamic treatment'
    Promotor: Prof. dr. A. Brand
    Co-promotor: Dr. J.W.M. Lagerberg
    University of Leiden

  • Andrea Rachinger
    16 April 2010
    'Hiv-1 Superinfection In Homosexual Men'
    Promotor: Prof. dr. H. Schuitemaker
    Co-promotor: dr. A.B. van ’t Wout
    University of Amsterdam

    5 March 2010
    'HIV-1 neutralizing humoral immunity, viral evolution and disease progression'
    Promotor: Prof.dr. H. Schuitemaker
    University of Amsterdam
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    30 March 2010
    'Processing of apoptotic cells in health and systemic autoimmune disease'
    Promotor: Prof. dr. L.A. Aarden
    University of Amsterdam
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    PhD theses 2009

    1 December 2009
    ‘MHC class II antigen presentation by B cells in health and disease’
    Promotores: Prof. dr. J.J. Neefjes and prof. dr.C.J.L.M. Meijer
    Co-promotor: Dr. S.M. van Ham
    University of Leiden
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    29 September 2009
    'Toll-like Receptors: Tools, Assays, and Implications for in-vitro Pyrogen Tests'
    Promotor: Prof. dr. L.A. Aarden
    University of Amsterdam
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    22 September 2009
    'Clinical and immunological aspects of pretransplant blood transfusions'
    Promotors: Prof. dr. F.H.J. Claas and prof. dr. A. Brand
    University of Leiden
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    23 June 2009
    'Cellular factors involved in HIV-1 replication'
    Promotor: Prof. dr. J. Schuitemaker
    Co-promotor: dr. N.A. Kootstra
    University of Amsterdam
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    15 May 2009
    ‘Towards primary prevention of rheumatoid arthritis: autoantibodies in the (pre) clinical phase’
    Promotores: Prof. dr. B.A.C. Dijkman and prof. dr. L. Aarden
    Co-promotor: Dr. D. van Schaardenburg
    Free University of Amsterdam
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    20 March 2009
    ‘The systematic recruitment of new blood donors’
    Promotores: Prof.dr. H.P. Schaalma (University of Maastricht) and prof.dr. C. Abraham (University of Sussex, England)
    Copromotor: Dr. R.A.C. Ruiter (University of Maastricht)
    University of Maastricht
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    13 March 2009
    'Signal regulatory protein alpha in phagocyte function'
    Promotor: Prof. dr G. Kraal and prof. dr. C.D. Dijkstra
    Co-promotor: Dr. T.K. van den Berg
    Free University of Amsterdam
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    6 March 2009
    ‘Cellular immunity driving HIV-1 evolution’
    Promotor: Prof.dr. J. Schuitemaker
    Co-promotor: dr. N. Kootstra
    University of Amsterdam
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    20 January 2009
    'Mitochondria in Neutrophil Apoptosis’
    Promotores: Prof.dr. T.W. Kuijpers and prof. dr. D. Roos
    Co-promotor: Dr. A.J. Verhoeven
    University of Amsterdam
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    14 January 2009
    ‘Detection and Prevention of Pregnancy Immunisation. The OPZI study’
    Promotores: Prof. dr C.E. van der Schoot and prof. dr. G.J. Bonsel
    Copromotores: Dr. M. de Haas and dr. T.G.M. Vrijkotte
    University of Amsterdam
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    PhD theses 2008

    12 September 2008
    'Supporting cells in neovascularization -study on candidates for cellular therapy-'
    Promotor: Prof. dr. C.E. van der Schoot
    Co-promotor: Dr. J.J. Zwaginga
    University of Amsterdam
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    5 September 2008
    ‘Platelet-monocyte complexes in touch with the endothelium’
    Promotor: Prof. dr. D. Roos
    Co-promotores: Dr. P.L. Hordijk and dr. J.J. Zwaginga
    University of Amsterdam
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    27 August 2008
    'Factor VIII trafficking to Weibel-Palade bodies'
    Promotores: Prof. dr. K. Mertens and prof. dr. G. Storm
    Co-promotores: Dr. J. Voorberg and dr. N.A. Kootstra
    University of Utrecht
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    26 June 2008
    'The role of Mannose-Binding Lectin in Vitro and in Vivo'
    Promotores: Prof. dr. T.W. Kuijpers and prof. dr. D. Roos
    Co-promotor: Dr. K.M. Dolman
    University of Amsterdam
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    19 June 2008
    'Assessment of complement activation in human disease'
    Promotores: Prof. dr. L.A. Aarden and Prof. dr. C.E. Hack
    University of Amsterdam
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    18 March 2008
    'The human Immune Response to Rh Antigens'
    Promotor: Prof. dr. C.E. van der Schoot (Sanquin Research)
    University of Amsterdam
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    16 January 2008
    ‘Red blood cell alloimmunization after blood transfusion’
    Promotor: Prof. dr. A. Brand (Sanquin Blood Bank Southwest Region)
    University of Leiden
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    15 January 2008
    ‘From stem cell to platelet’
    Promotores: Prof. dr. D. Roos and prof. dr. C.E. van der Schoot (Sanquin Research)
    Co-promotores: Dr. J.J. Zwaginga and dr. C. Voermans (Sanquin Research)
    University of Amsterdam
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    PhD theses 2007

  • Wilfried Levering
    24 October 2007
    'External quality assessment in flow cytometry: educational aspects and trends towards improvements’
    Promotor: Prof.dr. D.J. van Rhenen (Sanquin Blood Bank South West Region)
    Co-promotor: dr. J.W. Gratama
    Erasmus University Rotterdam

  • Ruben Bierings
    17 October 2007
    ‘Sorting out the Weibel-Palade body’
    Promotor: Prof. dr. K. Mertens (Faculty of Pharmaceutical Sciences, University of Utrecht and Sanquin Research, Amsterdam)
    Co-promotores: dr. J.A. van Mourik and dr. J. Voorberg (Sanquin Research and Sanquin Diagnostic Services)
    University of Utrecht
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  • Niubel Diaz Padilla
    13 September 2007
    ‘Role of IgM and C-reactive protein in Ischemia reperfusion injury’
    Promotor: Prof.dr. M.R. Daha (Department of Nephrology, Leiden University Medical Center)
    University of Leiden

  • Pauline van Helden
    3 July 2007
    'Immune tolerance induction in Hemophilia A'
    Promotor: Prof. K. Mertens (Faculty of Pharmaceutical Sciences, University of Utrecht and Sanquin Research, Amsterdam) and dr. H.M. van den Berg
    Copromotor: Dr. J. Voorberg
    University of Utrecht
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  • Sandra Cauwenberghs
    20 June 2007
    'Platelet responsiveness and function during storage (implications for platelet transfusion therapy)'
    Promotor: Prof. Dr. J. Rosing (University of Maastricht)
    Co-promotores: Dr. J.W.M. Heemskerk (University of Maastricht) and Dr. J. Curvers (Sanquin Blood Bank Southeast Region)
    Universiteit of Maastricht
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  • Fokke Terpstra
    19 June 2007
    ‘Viral Safety of Blood and Plasma products’
    Promotor: Prof.dr. H. Schuitemaker (Sanquin Research)
    Co-promotores: dr A.B. van 't Wout (Sanquin Research) and dr J. Over (Sanquin Plasma Products)
    University of Amsterdam
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  • Maarten Biezeveld
    28 March 2007
    ‘Genes and Proteins in Kawasaki Disease’
    Promotor: Prof. dr. T.W. Kuijpers
    University of Amsterdam
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  • Esther Quakkelaar
    23 March 2007
    ‘Antibody neutralization of HIV-1’
    Promotor: Prof. dr. H. Schuitemaker
    University of Amsterdam
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  • Magdalena Lorenowicz
    8 March 2007
    'Beyond the Borders: Signaling in Cell Adhesion and Migration'
    Promotor: Prof. dr. D Roos (Sanquin Research, Amsterdam)
    Co-promotor: Dr. P.L. Hordijk (Sanquin Research, Amsterdam)
    University of Amsterdam
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  • Nienke Vrisekoop
    1 March 2007
    'T-cell dynamicx in healthy and HIV-infected individuals'
    Promotor: Prof.dr. F. Miedema
    Co-promotores: Dr. J.A.M. Borghans and dr. K. Tesselaar
    University of Utrecht
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  • Sacha Zeerleder
    1 February 2007
    ‘Studies on inflammatory and coagulation pathways in humans with sepsis’
    Promotors: Prof. dr. C.E. Hack and prof. dr. W.A. Wuillemin
    University of Amsterdam
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  • Gerard Jansen
    11 January 2007
    ‘Evidence based studies in clinical transfusion medicine’
    Promotor: Prof. dr. D.J. van Rhenen (Sanquin Blood Bank South West Region)
    Copromotor: dr. J.J. Duvekot
    Erasmus MC University in Rotterdam

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    PhD theses 2006

  • Jean Paul ten Klooster
    30 November 2006
    'Rac1 Targeting and Signalling - A hypervariable point of view’
    Promotor: Prof. dr. D Roos (Sanquin Research, Amsterdam)
    Co-promotor: Dr. P.L. Hordijk (Sanquin Research, Amsterdam)
    University of Amsterdam
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  • Marco Koppelman
    28 June 2006
    'Viral safety of blood donations: molecular detection of blood transmittable viruses'
    Promotor: Prof. dr. J. Schuitemaker (Sanquin Research)
    Co-promotores: Dr. J. Zaaijer and dr. H.W. Reesink (Sanquin Blood Bank Northwest Region)
    University of Amsterdam
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  • Mettine Bos
    28 March 2006
    'Regulatory mechanisms in the inactivation of blood coagulation factors V en VIII'
    Promotor: Prof. dr. K. Mertens (Faculty of Pharmaceutical Sciences, University of Utrecht and Sanquin Research, Amsterdam)
    Co-promotor: Dr. A.B. Meijer (Sanquin Research, Amsterdam)
    University of Utrecht
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  • Bahram Alamdary Badlou
    13 March 2006
    ‘Prolonged platelet preservation by metabolic suppression’
    Promotor: Prof. dr. J.W.N. Akkerman
    Co-promotor: Dr. W.M. Smid (Sanquin Blood Bank North West Region)
    University of Utrecht
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  • Tamimount Mohammadi
    8 February 2006
    'Bacterial contamination of platelet concentrates: Molecular tools and applications'
    Promotor: Prof.dr. C.M.J.E. Vandenbroucke-Grauls (Free University Amsterdam)
    Co-promotores: Dr. P.H.M. Savelkoul and Dr. H.W. Reesink (Sanquin Blood Bank North West Region)
    Free University
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  • Brenda Luken
    30 January 2006
    'Antibodies directed to ADAMTS13 in acquired thrombotic thrombocytopenic purpuras'
    Promotor: Prof. dr. K. Mertens (Faculty of Pharmaceutical Sciences, University of Utrecht and Sanquin Research, Amsterdam)
    Copromotors: Dr. J. Voorberg (Sanquin Research) and dr. R. Fijnheer
    University of Utrecht
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  • Mariska Rondaij
    16 January 2006
    'Regulation of Weibel-Palade body exocytosis in human endothelial cells'
    Promotor: Prof. dr. K. Mertens (Faculty of Pharmaceutical Sciences, University of Utrecht and Sanquin Research, Amsterdam)
    Copromotors: Dr. J.J. Voorberg and dr. M. Fernandez Borja (Sanquin Research, Amsterdam)
    University of Utrecht
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  • Martine Grootkerk-Tax
    11 January 2006
    ‘Rh Variability in Multi-Ethnic Perspective - Consequences for RH Genotyping’
    Promotor: Prof. dr. D.J. van Rhenen (Sanquin Blood Bank Southwest Region)
    Copromotores: dr. P.A. Maaskant-van Wijk (Sanquin Blood Bank Southwest Region) and dr. C.E. van der Schoot (Sanquin Research)
    Erasmus University Rotterdam
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    PhD theses 2005

  • Jaap Akkerdaas
    2 November 2005
    "Identification and Quantification of Hazelnut Allergens"
    Promotor: Prof. R.C. Aalberse (Sanquin Research at CLB, Amsterdam)
    Co-promotor: Dr. R. van Ree (Sanquin Research at CLB, Amsterdam)
    University of Amsterdam
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  • Caroline Fribourg
    28 October 2005
    “Catalytic function of coagulation factor IX”
    Promotor: Prof. dr. K. Mertens (Faculty of Pharmaceutical Sciences, University of Utrecht and Sanquin Research at CLB, Amsterdam)
    University of Utrecht
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  • Paula da Costa Martins
    26 October 2005
    "Biology of monocyte interactions with the endothelium - the platelet factor -"
    Promotor: Prof. dr. D. Roos (Sanquin Research at CLB, Amsterdam)
    Co-promotor: Dr. J.J. Zwaginga (Sanquin Research at CLB, Amsterdam)
    University of Amsterdam
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  • Edwin van Mirre
    20 October 2005
    "Novel insights in Human Fcγ-receptors and IgG: on genes, transcripts and functional interactions”
    Promotores: Prof. dr. C.E. Hack (Sanquin Research at CLB) and prof.dr. T.W. Kuijpers (Sanquin Research, at CLB en Academic Medical Center University of Amsterdam)
    University of Amsterdam
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  • Christine Jansen
    13 May 2005
    "Analysis of HIV-specific T-cell immunity in AIDS-pathogenesis"
    Promotor: Prof.dr. F. Miedema
    Co-promotor: Dr. D. van Baarle
    University of Utrecht
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  • Atoosa Familian
    15 April 2005
    "Studies on pentraxin mediated complement activation"
    Promotores: Prof.dr. C.E. Hack (Sanquin Research at CLB) and Prof.dr. B.A.C. Dijkmans
    Free University Amsterdam
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  • Corine Bronke
    24 March 2005
    "Cytomegalovirus-specific T-cell dynamics in HIV infection"
    Promotor: Prof.dr. F. Miedema (Sanquin Research at CLB)
    Co-promotores: Dr. D. van Baarle and dr. K. Tesselaar (Sanquin Research at CLB)
    University of Amsterdam
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  • Erwan Piriou
    31 March 2005
    "Viro-immunology of EBV-HIV co-infection"
    Promotores: Prof.dr. F. Miedema (Sanquin Research at CLB) and prof. dr. M.H.J. van Oers
    Co-promotor: Dr. D. van Baarle (Sanquin Research at CLB)
    University of Amsterdam
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    PhD theses 2004

  • Martine Hollestelle
    17 December 2004
    "Factor VIII expression and regulation in health and disease"
    Promotor: Prof. dr. K. Mertens (Faculty of Pharmaceutical Sciences, University of Utrecht and Sanquin Research at CLB, Amsterdam)
    Copromotor: Dr. J.C. van Mourik (Sanquin Research at CLB, Amsterdam)
    University of Amsterdam
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  • Aster Tsegaye
    15 December 2004
    "T cell dynamics and HIV specific CTL responses in Ethiopians"
    Promotor: Prof. dr. F. Miedema (Sanquin Research at CLB)
    University of Amsterdam
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  • Jakub Rohlena
    13 December 2004
    "Molecular interactions between coagulation factor IX and low density lipoprotein receptor-related protein"
    Promotor: Prof. dr. K. Mertens (Faculty of Pharmaceutical Sciences, University of Utrecht and Sanquin Research at CLB, Amsterdam)
    Copromotor: Dr. P.J. Lenting
    University of Utrecht
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  • Fransje Koning
    26 November 2004
    "Determinants of host HIV-1 suspectibility and R5 HIV-1 evolution"
    Promotores: Prof. dr. F. Miedema and prof.dr. J. Schuitemaker (Sanquin Research at CLB, Amsterdam)
    University of Amsterdam
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  • Margriet Dijkstra-Tiekstra
    17 November 2004
    "Biomedical Excellence for Safer Transfusion of Platelet Concentrates. BEST of PCs"
    Promotor: Prof.dr. P.C. Huijgens
    Copromotores: dr. H.W. Reesink and dr. R.N.I. Pietersz (Sanquin Blood Bank North West Region)
    Free University of Amsterdam
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  • Herm-Jan Brinkman
    10 November 2004
    "Endothelial cells, their procoagulant side"
    Promotor: Prof. dr. K. Mertens (Faculty of Pharmaceutical Sciences, University of Utrecht en Sanquin Research at CLB, Amsterdam)
    Copromotor: Dr. J.C. van Mourik (Sanquin Research at CLB, Amsterdam)
    University of Utrecht
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  • Caroline Ciurana
    28 October 2004
    "Molecular mechanisms of complement activation by damaged cells"
    Promotor: Prof.dr. C.E. Hack (Sanquin Research at CLB, Amsterdam)
    University of Amsterdam
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  • Marrie Bruin
    15 October 2004
    "Neutropenia and trombocytopenia in children; clinical relevance of old and new laboratory tests"
    Promotores: Prof.d.r. B.J.M. Zegers and prof.dr. D. Roos (Sanquin Research at CLB, Amsterdam)
    University of Amsterdam
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  • Nikolai Maianski
    4 June 2004
    "Neutrophil cell death: mechanisms and regulation"
    Promotores: Prof. dr. T.W. Kuijpers (Sanquin Research at CLB and Academic Medical Center, University of Amsterdam) and Prof. dr. D. Roos (Sanquin Research at CLB, Amsterdam)
    University of Amsterdam
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  • Sacha de Lathouder
    3 June 2004
    "Inhibition of cytokine production by methotrexate. Studies in healthy volunteers and patients with rheumatoid arthritis"
    Promotores: Prof. dr. L. Aarden (Sanquin Research at CLB, Amsterdam) and prof. dr. B.A.C. Dijkmans
    University of Amsterdam
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  • Jaap van Buul
    14 May 2004
    "Signalling in leukocyte-transendothelial migration: a roadmap for the homing of progenitor cells"
    Promotor: Prof. dr. D. Roos (Sanquin Research at CLB, Amsterdam)
    Copromotores: Dr. P.L. Hordijk and dr. C.E. van der Schoot (Sanquin Research at CLB, Amsterdam)
    University of Amsterdam
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  • Robin van Bruggen
    28 April 2004
    "Build fot the kill: studies on the neutrophil and NADPH-oxydase"
    Promotor: Prof. dr. D. Roos (Sanquin Research at CLB, Amsterdam)
    Copromores: Prof. dr. T.W. Kuijpers and Dr. R.S. Weening (Sanquin Research at CLB, Amsterdam and Academic Medical Center University of Amsterdam)
    University of Amsterdam
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  • Aran Labrijn
    24 February 2004
    "Neutralizing Antibodies to theHIV-1 Envelope Glycoproteins"
    Promotor: Prof. dr. C. E. Hack (Sanquin Research at CLB, Amsterdam)
    Co-promotores: dr. J.G. Huisman and dr. P.W.H.I. Parren
    University of Amsterdam
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  • Mirte Hemker
    18ebruary 2004
    "A study of weak D and the function of the Rh Complex in red blood cells"
    Promotor: Prof.dr. D.J. van Rhenen (Sanquin Blood Bank South West Region)
    Copromotors: Dr. C.E. van der Schoot (Sanquin Research at CLB, Amsterdam) en Dr. P.A. Maaskant-van Wijk
    Erasmus Univerity of Rotterdam
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  • Leo van de Watering
    5 February2004
    "Perioperative blood transfusions and their complications"
    Promotors: Prof. dr. A. Brand (Sanquin Blood Bank South West Region) and prof. dr. C van de Velde
    University of Leiden
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    PhD theses 2003

  • Ineke Bos
    21 November2003
    “C1-Inhibitor potentiation by glycosaminiglycans”
    Promotor: Prof. dr. C.E. Hack (Sanquin Research at CLB, Amsterdam) and prof.dr. J.P. Abrahams
    Copromotor: Dr. E. Eldering
    University of Amsterdam
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  • Erica van Oort
    19 September 2003
    “Pros and Cons of Natural and Recombinant Allergens”
    Promotor: Prof. dr. R.C. Aalberse (Sanquin Research at CLB, Amsterdam)
    Copromotor: Dr. R. van Ree (Sanquin Research at CLB, Amsterdam)
    University of Amsterdam
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  • Niels Bovenschen
    16 June 2003
    "The Interaction between Coagulation Factor VIII and Its Clearance Receptors"
    Promotor: Prof. dr. K. Mertens (Faculty of Pharmaceutical Sciences, University of Utrecht and Sanquin Research at CLB, Amsterdam)
    Copromotors: Dr. A.B. Meijer and Dr. P.J. Lenting
    University of Utrecht
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  • Wendy Bril
    22 May 2003
    “Factor VIII inhibitors in mild haemophilia A”
    Promotor: Prof. dr. K. Mertens (Faculty of Pharmaceutical Sciences, University of Utrecht and Sanquin Research, CLB, Amsterdam) and Prof. dr. R.A.W. van Lier (AMC, Amsterdam)
    Copromotor: Dr. J.J. Voorberg (Sanquin Research at CLB, Amsterdam)
    University of Utrecht
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  • Christof Meischl
    1 April 2003
    "NADPH oxidases and mutation analysis"
    Promotor: Prof. dr. D. Roos (Sanquin Research at CLB, Amsterdam)
    University of Amsterdam
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  • Thalia Romani de Wit
    20Februari 2003
    "Weibel-Palade bodies. An exciting way out!"
    Promotor: Prof. dr. K. Mertens (Faculty of Farmaceutical Sciences, University of Utrecht and Sanquin Research at CLB, Amsterdam)
    Co-promotor: Dr. J.A. van Mourik (Sanquin Research at CLB, Amsterdam)
    University of Utrecht
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    PhD theses 2002

  • David Kwa
    12 December 2002
    "Host and viral factors in AIDS pathogenesis"
    Promotor: Prof. dr. F. Miedema (Sanquin Research at CLB, Amsterdam)
    Co-promotor: Dr. H. Schuitemaker (Sanquin Research at CLB, Amsterdam)
    University of Amsterdam
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  • Dominique Reumaux
    1 November 2002
    "Anti-neutrophil cytoplasm autoantibodies (ANCA). Clinical and functional studies"
    Promotores: Prof. dr. D. Roos (Sanquin Research at CLB, Amsterdam) and prof. dr. P. Duthilleul
    University of Amsterdam
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  • Mette Hazenberg
    13 September 2002
    "T cell turnover and thymic function in HIV-1 infection"
    Promotor: Prof. dr. F. Miedema (Sanquin Research at CLB, Amsterdam)
    Co-promotores: Dr. D. Hamann (Sanquin Research at CLB, Amsterdam) and dr. R.J. de Boer
    University of Amsterdam
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  • Lauro Ribeiro do Couto
    4 July 2002
    "Control of cytotoxic responses on human neonates: naivety or tigh regulation?"
    Promotor: Prof. dr. L.A. Aarden (Sanquin Research at CLB, Amsterdam)
    Co-promotor: Dr. C.J.P. Boog
    University of Amsterdam
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  • John Jongerius
    21 June 2002
    "Detection of blood transmissible viral agents"
    Promotor: Prof.dr. W.G. van Aken (Sanquin, CLB, Amsterdam)
    Copromotores: Dr. E.F. van Leeuwen (Blood Bank North West Region) and dr. C.L. van der Poel (Sanquin)
    University of Amsterdam
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  • Tim Beaumont
    14 June 2002
    "HIV-1 sensitivity to neutralization: biological and molecular studies"
    Promotor: Prof. dr. F. Miedema (Sanquin Research at CLB, Amsterdam)
    Copromotor: Dr. J. Schuitemaker (Sanquin Research at CLB, Amsterdam)
    University of Amsterdam
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  • Ronald van Rij
    21 March 2002
    "Chemokine Receptors in HIV-1 infection and AIDS pathogenesis"
    Promotor: Prof. dr. F. Miedema (Sanquin Research at CLB, Amsterdam)
    Co-promotor: Dr. J. Schuitemaker (Sanquin Research at CLB, Amsterdam)
    University of Amsterdam
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